Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.37 |
| ▸ | LCK | P06239 | 6/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7025397 | 0.75 | MAP3K14 (0.49) | MAP3K14LCKMKNK2MKNK1ROCK1 | |
| SCHEMBL7017821 | 0.74 | LCK (0.56) | MAP3K14LCKMKNK2MKNK1ROCK1 | |
| SCHEMBL7567370 | 0.71 | MAP3K14 (0.46) | MAP3K14LCKMKNK2MKNK1ROCK1 | |
| SCHEMBL7508933 | 0.68 | LCK (0.56) | MAP3K14LCKMKNK2MKNK1ROCK1 | |
| SCHEMBL7497927 | 0.67 | MAP3K14 (0.41) | MAP3K14LCKMKNK2MKNK1ROCK1 | |
| SCHEMBL7658448 | 0.61 | LCK (0.40) | MAP3K14LCKMKNK2MKNK1ROCK1 | |
| SCHEMBL7018158 | 0.60 | LCK (0.46) | LCKMKNK2MKNK1 | |
| SCHEMBL7504836 | 0.59 | MKNK1 (0.59) | LCKMKNK2MKNK1 | |
| SCHEMBL7503109 | 0.58 | MAPT (0.50) | — | |
| SCHEMBL7024205 | 0.56 | LCK (0.71) | MAP3K14LCKMKNK2MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |