Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 9/20 | 0.40 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7508933 | 0.78 | LCK (0.56) | LCKMAP3K14MKNK2MKNK1ROCK1 | |
| SCHEMBL7025397 | 0.72 | MAP3K14 (0.49) | LCKMAP3K14MKNK2MKNK1ROCK1 | |
| SCHEMBL7017821 | 0.72 | LCK (0.56) | LCKMAP3K14MKNK2MKNK1ROCK1 | |
| SCHEMBL7567370 | 0.69 | MAP3K14 (0.46) | LCKMAP3K14MKNK2MKNK1ROCK1 | |
| SCHEMBL7497927 | 0.69 | MAP3K14 (0.41) | LCKMAP3K14MKNK2MKNK1ROCK1 | |
| SCHEMBL7503109 | 0.63 | MAPT (0.50) | — | |
| SCHEMBL7499093 | 0.61 | MAP3K14 (0.37) | LCKMAP3K14MKNK2MKNK1ROCK1 | |
| SCHEMBL9381224 | 0.58 | MAPT (0.56) | — | |
| SCHEMBL7499363 | 0.58 | MKNK1 (0.67) | LCKMKNK2MKNK1 | |
| SCHEMBL7020879 | 0.58 | LCK (0.90) | LCKMKNK2MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6498165-B1 | PYRIMIDINE COMPOUNDS; PROPHYLAXIS AND TREATMENT OF SUCH AS IMMUNE DISEASES, HYPERPROLIFERATIVE DISORDERS, CANCER, ANGIOGENSIS, ATHEROSCELEROSIS, GRAFT REJECTION, RHEUMATOID ARTHRITIS, PSORIASIS | MERCK & CO., INC. | 2002-12-24 | — | — | US | disclosed |