Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.46 |
| ▸ | LCK | P06239 | 6/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7025397 | 0.85 | MAP3K14 (0.49) | MAP3K14LCKROCK1MKNK2MKNK1 | |
| SCHEMBL7017821 | 0.84 | LCK (0.56) | MAP3K14LCKROCK1MKNK2MKNK1 | |
| SCHEMBL7508933 | 0.78 | LCK (0.56) | MAP3K14LCKROCK1MKNK2MKNK1 | |
| SCHEMBL7497927 | 0.77 | MAP3K14 (0.41) | MAP3K14LCKROCK1MKNK2MKNK1 | |
| SCHEMBL7017709 | 0.73 | LCK (0.74) | LCKMKNK2MKNK1 | |
| SCHEMBL7017711 | 0.73 | MKNK2 (0.63) | LCKMKNK2MKNK1 | |
| SCHEMBL19848423 | 0.73 | HTT (0.59) | ALDH1A1HPGDMAPK1HTTMAPK10 | |
| SCHEMBL7499093 | 0.71 | MAP3K14 (0.37) | MAP3K14LCKROCK1MKNK2MKNK1 | |
| SCHEMBL7018158 | 0.70 | LCK (0.46) | LCKMKNK2MKNK1HPGD | |
| SCHEMBL7658448 | 0.69 | LCK (0.40) | MAP3K14LCKCDK2ROCK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |