SCHEMBL7499126

SCHEMBL7499126

O=C(O)NC(=O)C12CCCN(CCC1)C2

nearest known ligand 0.51

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 1/20 0.37
CHRM4 P08173 1/20 0.37
CHRM1 P11229 1/20 0.37
CHRM3 P20309 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7495583 0.96 CHRM2 (0.42) CHRM2CHRM4CHRM1CHRM3
SCHEMBL7495564 0.88 CHRM2 (0.36) CHRM2CHRM4CHRM1CHRM3
SCHEMBL3951763 0.77 CHRM2 (0.39) CHRM2CHRM4CHRM1CHRM3
Hydrochloric Acid SCHEMBL9051821 0.75 CHRM2 (0.38) CHRM2CHRM4CHRM1CHRM3
SCHEMBL7497891 0.75 GSK3B (0.30)
SCHEMBL205297 0.74 CHRM2 (0.44) CHRM2CHRM4CHRM1CHRM3
SCHEMBL8790867 0.73 CHRM2 (0.35) CHRM2CHRM4CHRM1CHRM3
Hydrochloric Acid SCHEMBL2421629 0.72 CHRM2 (0.42) CHRM2CHRM4CHRM1CHRM3
SCHEMBL205678 0.71 CHRM2 (0.38) CHRM2CHRM4CHRM1CHRM3
SCHEMBL9458387 0.71 CHRM2 (0.38) CHRM2CHRM4CHRM1CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934316-B1 AZABICYCLIC CARBAMOYLOXY MUTILIN DERIVATIVES FOR ANTIBACTERIAL USE SMITHKLINE BEECHAM PLC (GB) 2002-10-16 EP claimed
US-6121281-A Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use SMITHKLINE BEECHAM P.L.C. (GB) 2000-09-19 US claimed
EP-0934316-B1 AZABICYCLIC CARBAMOYLOXY MUTILIN DERIVATIVES FOR ANTIBACTERIAL USE SMITHKLINE BEECHAM PLC (GB) 2002-10-16 EP disclosed
US-6121281-A Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use SMITHKLINE BEECHAM P.L.C. (GB) 2000-09-19 US disclosed
EP-0934316-A1 AZABICYCLIC CARBAMOYLOXY MUTILIN DERIVATIVES FOR ANTIBACTERIAL USE SMITHKLINE BEECHAM PLC (GB) 1999-08-11 EP disclosed
WO-1998005659-A1 AZABICYCLIC CARBAMOYLOXY MUTILIN DERIVATIVES FOR ANTIBACTERIAL USE SMITHKLINE BEECHAM PLC (GB) 1998-02-12 WO disclosed