SCHEMBL205297

SCHEMBL205297

O=C(O)C12CCCN(CC1)C2

nearest known ligand 0.61

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 2/20 0.44
CHRM4 P08173 2/20 0.44
CHRM1 P11229 2/20 0.44
CHRM3 P20309 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31731969 1.00 CHRM2 (0.44) CHRM2CHRM4CHRM1CHRM3
Hydrochloric Acid SCHEMBL2421629 0.98 CHRM2 (0.42) CHRM2CHRM4CHRM1CHRM3
SCHEMBL3951763 0.96 CHRM2 (0.39) CHRM2CHRM4CHRM1CHRM3
Hydrochloric Acid SCHEMBL9051821 0.93 CHRM2 (0.38) CHRM2CHRM4CHRM1CHRM3
SCHEMBL2556850 0.91 CHRM2 (0.37) CHRM2CHRM4CHRM1CHRM3
Hydrochloric Acid SCHEMBL4198612 0.89 CHRM2 (0.36) CHRM2CHRM4CHRM1CHRM3
SCHEMBL14351404 0.89 CHRM2 (0.36) CHRM2CHRM4CHRM1CHRM3
SCHEMBL8790867 0.86 CHRM2 (0.35) CHRM2CHRM4CHRM1CHRM3
SCHEMBL9049033 0.81 CHRM2 (0.42) CHRM2CHRM4CHRM1CHRM3
SCHEMBL8557075 0.81 CHRM2 (0.46) CHRM2CHRM4CHRM1CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0287356-B1 Bridgehead substituted azabicyclic derivatives BEECHAM GROUP PLC (GB) 1996-01-24 EP claimed
EP-4493556-A1 NLRP3 MODULATORS Zomagen Biosciences Ltd (US) 2025-01-22 EP disclosed
CN-119301116-A NLRP3 modulators 祖玛珍生物科学有限公司 2025-01-10 CN disclosed
CN-118076599-A Dioxazines and their use in the treatment of GBA related diseases 泽拉丹麦有限公司 2024-05-24 CN disclosed
US-20230295113-A1 NLRP3 MODULATORS ZOMAGEN BIOSCIENCES LTD 2023-09-21 US disclosed
WO-2023178099-A1 NLRP3 MODULATORS ZOMAGEN BIOSCIENCES LTD (US) 2023-09-21 WO disclosed
WO-2023178099-A1 NLRP3 MODULATORS ZOMAGEN BIOSCIENCES LTD (US) 2023-09-21 WO disclosed
US-20230295113-A1 NLRP3 MODULATORS ZOMAGEN BIOSCIENCES LTD 2023-09-21 US disclosed
US-20230295113-A1 NLRP3 MODULATORS ZOMAGEN BIOSCIENCES LTD 2023-09-21 US disclosed
EP-2997032-A1 6-BRIDGED HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION F. Hoffmann-La Roche AG (CH) 2016-03-23 EP disclosed
WO-2014184328-A1 6-BRIDGED HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION F. HOFFMANN-LA ROCHE AG (CH) 2014-11-20 WO disclosed
US-8088760-B2 Benzoxazole carboxamide inhibitors of poly(ADP-ribose)polymerase (PARP) BIOMARIN PHARMACEUTICAL INC. (US) 2012-01-03 US disclosed
EP-2247600-A2 BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) Lead Therapeutics, Inc. (US) 2010-11-10 EP disclosed
WO-2009099736-A2 BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) LEAD THERAPEUTICS, INC. (US) 2009-08-13 WO disclosed
US-20090197863-A1 BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) LEAD THERAPEUTICS, INC. (US) 2009-08-06 US disclosed
US-20090062268-A1 NOVEL INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) LEAD THERAPEUTICS, INC. (US) 2009-03-05 US disclosed
EP-0287356-B1 Bridgehead substituted azabicyclic derivatives BEECHAM GROUP PLC (GB) 1996-01-24 EP disclosed
EP-0625981-A1 AZABICYCLO COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1994-11-30 EP disclosed
WO-1993015080-A1 AZABICYCLO COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1993-08-05 WO disclosed
EP-0287356-A2 Bridgehead substituted azabicyclic derivatives BEECHAM GROUP PLC (GB) 1988-10-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090197863-A1 BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) PARP1, PARP2, PARP11 CHRM2 4479/4885CHRM4 4734/4885CHRM1 4421/4885
US-20090062268-A1 NOVEL INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) PARP1, PARP11, PARP2 CHRM2 4390/4885CHRM4 4831/4885CHRM1 4381/4885
US-20230295113-A1 NLRP3 MODULATORS NLRP3, NLRP1, NOD1 CHRM2 4474/4885CHRM4 4362/4885CHRM1 4579/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.