Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 10/20 | 0.62 |
| ▸ | HTR2C | P28335 | 10/20 | 0.62 |
| ▸ | HTR2B | P41595 | 6/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | HTR1D | P28221 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PNMT | P11086 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.30 |
| ▸ | EED | O75530 | 1/20 | 0.30 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.30 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7493732 | 0.92 | HTR2C (0.64) | HTR2AHTR2CHTR2BALDH1A1LMNA | |
| SCHEMBL8888063 | 0.92 | HTR2C (0.65) | HTR2AHTR2CHTR2BALDH1A1LMNA | |
| SCHEMBL8888882 | 0.83 | HTR2C (0.67) | HTR2AHTR2CHTR2BALDH1A1LMNA | |
| Ammonia Solution, Strong SCHEMBL906002 | 0.82 | HTR2C (0.64) | HTR2AHTR2CHTR2BALDH1A1LMNA | |
| SCHEMBL25882779 | 0.80 | HTR2C (0.68) | HTR2AHTR2CHTR2BALDH1A1LMNA | |
| SCHEMBL4935456 | 0.80 | HTR2C (0.61) | HTR2AHTR2CHTR2BALDH1A1LMNA | |
| SCHEMBL8890016 | 0.77 | HTR2A (0.61) | HTR2AHTR2CHTR2BALDH1A1LMNA | |
| SCHEMBL905999 | 0.77 | HTR2C (1.00) | HTR2AHTR2CHTR2BLMNAHTR1A | |
| SCHEMBL6328136 | 0.77 | HTR2C (1.00) | HTR2AHTR2CHTR2BLMNAHTR1A | |
| SCHEMBL8888059 | 0.77 | HTR2A (0.61) | HTR2AHTR2CHTR2BALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202964-A1 | CONDENSED INDOLINE DERIVATIVES AND THEIR USE AS 5HT, IN PARTICULAR 5HT2C, RECEPTOR LIGANDS | VERNALIS RESEARCH LIMITED (GB) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001012602-A1 | CONDENSED INDOLINE DERIVATIVES AND THEIR USE AS 5HT, IN PARTICULAR 5HT2C, RECEPTOR LIGANDS | VERNALIS RESEARCH LIMITED (GB) | 2001-02-22 | — | — | WO | disclosed |