Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | PPID | Q08752 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7499187 | 1.00 | SPHK1 (0.37) | SPHK1JAK2JAK1GPR119PPID | |
| SCHEMBL6719410 | 1.00 | SPHK1 (0.37) | SPHK1JAK2JAK1GPR119PPID | |
| SCHEMBL3612312 | 0.89 | SPHK1 (0.40) | SPHK1JAK2JAK1GPR119AKT1 | |
| SCHEMBL3612306 | 0.89 | SPHK1 (0.40) | SPHK1JAK2JAK1GPR119AKT1 | |
| SCHEMBL21802124 | 0.89 | TP53 (0.38) | PPIDL3MBTL1TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL2079206 | 0.81 | SLC6A2 (0.40) | SPHK1JAK2JAK1GPR119AKT1 | |
| SCHEMBL2079201 | 0.81 | SLC6A2 (0.40) | SPHK1JAK2JAK1GPR119AKT1 | |
| SCHEMBL21455299 | 0.80 | SPHK1 (0.43) | SPHK1L3MBTL1BRD4MEN1KMT2A | |
| SCHEMBL20867962 | 0.80 | SPHK1 (0.43) | SPHK1L3MBTL1BRD4MEN1KMT2A | |
| SCHEMBL21455156 | 0.80 | SPHK1 (0.43) | SPHK1L3MBTL1BRD4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1208097-A2 | SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS | Aventis Pharmaceuticals Inc. (US) | 2002-05-29 | — | — | EP | disclosed |
| WO-2001007436-A2 | SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS | AVENTIS PHARMACEUTICALS INC. (US) | 2001-02-01 | — | — | WO | disclosed |