Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.38 |
| ▸ | PPID | Q08752 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | F10 | P00742 | 2/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7499187 | 0.89 | SPHK1 (0.37) | TP53PPIDMAPTPIN1ALDH1A1 | |
| SCHEMBL6719410 | 0.89 | SPHK1 (0.37) | TP53PPIDMAPTPIN1ALDH1A1 | |
| SCHEMBL7499191 | 0.89 | SPHK1 (0.37) | TP53PPIDMAPTPIN1ALDH1A1 | |
| SCHEMBL3184733 | 0.76 | ALDH1A1 (0.54) | TP53PPIDMAPTPIN1ALDH1A1 | |
| SCHEMBL3612312 | 0.76 | SPHK1 (0.40) | TP53MAPTL3MBTL1 | |
| SCHEMBL3612306 | 0.76 | SPHK1 (0.40) | TP53MAPTL3MBTL1 | |
| SCHEMBL254781 | 0.74 | ALDH1A1 (0.53) | TP53PPIDMAPTPIN1ALDH1A1 | |
| SCHEMBL11180129 | 0.73 | ALDH1A1 (0.49) | TP53PPIDMAPTPIN1ALDH1A1 | |
| SCHEMBL5653101 | 0.73 | TP53 (0.44) | TP53PPIDMAPTPIN1ALDH1A1 | |
| SCHEMBL5653096 | 0.73 | TP53 (0.44) | TP53PPIDMAPTPIN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3559007-B1 | SULFONAMIDE COMPOUNDS HAVING TNAP INHIBITORY ACTIVITY | DAIICHI SANKYO CO LTD (JP) | 2023-08-16 | — | — | EP | disclosed |
| CN-110167946-B | Sulfonamide compounds having TNAP inhibitory activity | 第一三共株式会社 | 2022-04-08 | — | — | CN | disclosed |
| US-11046710-B2 | Sulfonamide compounds | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2021-06-29 | — | — | US | disclosed |
| US-11014939-B2 | — | — | 2021-05-25 | — | — | US | disclosed |
| US-20200087321-A1 | SULFONAMIDE COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2020-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200087321-A1 | SULFONAMIDE COMPOUNDS | ALPI, ASAH2, STS | TP53 3991/4885PPID 1168/4885MAPT 4589/4885 |
| US-11014939-B2 | — | ALPI, ALPP, ACER2 | TP53 4387/4885PPID 2144/4885MAPT 4182/4885 |
| US-11046710-B2 | Sulfonamide compounds | ALPI, ASAH2, STS | TP53 3991/4885PPID 1168/4885MAPT 4589/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.