SCHEMBL7499245

SCHEMBL7499245

Cc1c(N2CCCC(n3cccc3)C2)c(F)cn2c(=O)c(C(=O)O)cc(C3CC3)c12

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SCN5A Q14524 1/20 0.40
KCNH2 Q12809 9/20 0.38
ALDH1A1 P00352 3/20 0.36
KDM4E B2RXH2 2/20 0.36
NOTUM Q6P988 1/20 0.33
HPGD P15428 2/20 0.32
HSD17B10 Q99714 2/20 0.32
POLB P06746 2/20 0.32
OPRM1 P35372 2/20 0.32
CHRM2 P08172 1/20 0.32
CHRM1 P11229 1/20 0.32
OPRD1 P41143 1/20 0.32
PRKD3 O94806 1/20 0.31
ALOX15 P16050 1/20 0.31
CLK2 P49760 1/20 0.31
CLK4 Q9HAZ1 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
HRH3 Q9Y5N1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7503333 0.95 SCN5A (0.43) SCN5AKCNH2ALDH1A1KDM4ENOTUM
SCHEMBL7503330 0.95 SCN5A (0.43) SCN5AKCNH2ALDH1A1KDM4ENOTUM
SCHEMBL7502496 0.89 SCN5A (0.40) SCN5AKCNH2ALDH1A1KDM4ENOTUM
SCHEMBL8562588 0.86 ALDH1A1 (0.46) SCN5AKCNH2ALDH1A1KDM4EHPGD
SCHEMBL8566850 0.86 ALDH1A1 (0.46) SCN5AKCNH2ALDH1A1KDM4EHPGD
SCHEMBL14515902 0.86 SCN5A (0.40) SCN5AKCNH2ALDH1A1KDM4ENOTUM
SCHEMBL12590147 0.85 SCN5A (0.42) SCN5AKCNH2ALDH1A1KDM4EPOLB
SCHEMBL8561704 0.85 SCN5A (0.42) SCN5AKCNH2ALDH1A1KDM4EPOLB
SCHEMBL8564917 0.85 SCN5A (0.42) SCN5AKCNH2ALDH1A1KDM4EPOLB
Hydrochloric Acid SCHEMBL7502229 0.85 SCN5A (0.42) SCN5AKCNH2ALDH1A1KDM4EPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0723545-B1 QUINOLIZINONE TYPE COMPOUNDS ABBOTT LAB (US) 2002-05-08 EP claimed
CN-1053188-C Quinolizinone type compounds ABBOTT LAB (US) 2000-06-07 CN claimed
US-5599816-A BACTERICIDE ABBOTT LABORATORIES (US) 1997-02-04 US claimed
WO-1996039407-A1 QUINOLIZINONE TYPE COMPOUNDS ABBOTT LABORATORIES (US) 1996-12-12 WO claimed
CN-1137273-A Quinolizinone type compounds ABBOTT LAB (US) 1996-12-04 CN claimed
WO-1995010519-A1 QUINOLIZINONE TYPE COMPOUNDS ABBOTT LABORATORIES (US) 1995-04-20 WO claimed
EP-0723545-B1 QUINOLIZINONE TYPE COMPOUNDS ABBOTT LAB (US) 2002-05-08 EP disclosed
CN-1053188-C Quinolizinone type compounds ABBOTT LAB (US) 2000-06-07 CN disclosed
EP-0871628-A1 QUINOLIZINONE TYPE COMPOUNDS Abbott Laboratories (US) 1998-10-21 EP disclosed
US-5726182-A TREATMENT OF BACTERIAL INFECTIONS ABBOTT LABORATORIES (US) 1998-03-10 US disclosed
US-5599816-A BACTERICIDE ABBOTT LABORATORIES (US) 1997-02-04 US disclosed
WO-1996039407-A1 QUINOLIZINONE TYPE COMPOUNDS ABBOTT LABORATORIES (US) 1996-12-12 WO disclosed
CN-1137273-A Quinolizinone type compounds ABBOTT LAB (US) 1996-12-04 CN disclosed
US-5580872-A ADMINISTERING IN THE TREATMENT OF BACTERIAL INFECTIONS ABBOTT LABORATORIES (US) 1996-12-03 US disclosed
WO-1995010519-A1 QUINOLIZINONE TYPE COMPOUNDS ABBOTT LABORATORIES (US) 1995-04-20 WO disclosed