SCHEMBL7499361

SCHEMBL7499361

N#Cc1c(Br)c(C(F)(F)F)n(CBr)c1-c1ccc(Cl)cc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.37
HPGD P15428 4/20 0.37
MEN1 O00255 3/20 0.37
KMT2A Q03164 3/20 0.37
HTT P42858 2/20 0.37
ALDH1A1 P00352 2/20 0.37
LMNA P02545 2/20 0.37
GLA P06280 1/20 0.37
GAA P10253 1/20 0.37
CRHBP P24387 1/20 0.37
CRHR2 Q13324 1/20 0.37
MAPT P10636 2/20 0.33
POLB P06746 2/20 0.33
GRIA2 P42262 1/20 0.32
GRIA4 P48058 1/20 0.32
CNR1 P21554 1/20 0.32
USP2 O75604 1/20 0.32
THRB P10828 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
RXFP1 Q9HBX9 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7508068 0.90 KDM4E (0.37) KDM4EHPGDMEN1KMT2AHTT
SCHEMBL9057679 0.88 HTT (0.36) KDM4EHPGDMEN1KMT2AHTT
SCHEMBL9036743 0.88 KDM4E (0.38) KDM4EHPGDMEN1KMT2AHTT
SCHEMBL5819212 0.85 KDM4E (0.34) KDM4EHPGDMEN1KMT2AHTT
SCHEMBL9279148 0.83 POLB (0.34) KDM4EHPGDMEN1KMT2AHTT
Chlorfenapyr SCHEMBL40337 0.83 RXFP1 (0.35) KDM4EHPGDMEN1KMT2AHTT
SCHEMBL27916628 0.83 KDM4E (0.33) KDM4EHPGDMEN1KMT2AHTT
Chlorfenapyr SCHEMBL27488880 0.82 RXFP1 (0.35) KDM4EHPGDMEN1KMT2AHTT
Chlorfenapyr SCHEMBL28530561 0.82 RXFP1 (0.35) KDM4EHPGDMEN1KMT2AHTT
SCHEMBL9460941 0.82 POLB (0.36) KDM4EHPGDMEN1KMT2AHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5362746-A Process for the manufacture of insecticidal 2-aryl-1-(alkoxymethyl)-4-halo-5-(trifluoromethyl)pyrroles AMERICAN CYANAMID COMPANY (US) 1994-11-08 US claimed
EP-0492171-A1 2-Aryl-5-trifluoromethyl)-2-pyrroline compounds and process for the manufacture of insecticidal, 2-aryl-1-(alkoxymethyl)-4-halo-5-(trofluoromethyl) pyrroles AMERICAN CYANAMID COMPANY (US) 1992-07-01 EP claimed
EP-0530515-B1 Process for the preparation of N-halomethylpyrrole and intermediates BASF AG (DE) 2002-11-06 EP disclosed
EP-0826667-B1 2 Aryl 5 (trifluoromethyl) 2 pyrroline compounds and process for the manufacture of insecticidal, 2 aryl 1 (alkoxymethyl) 4 halo 5 (trifluoromethyl) pyrroles BASF AG (DE) 2002-10-30 EP disclosed
EP-0826667-A1 2 Aryl 5 (trifluoromethyl) 2 pyrroline compounds and process for the manufacture of insecticidal, 2 aryl 1 (alkoxymethyl) 4 halo 5 (trifluoromethyl) pyrroles AMERICAN CYANAMID COMPANY (US) 1998-03-04 EP disclosed
US-5378839-A Insecticidal, acaricidal and molluscicidal 1-(subsituted)thioalkylpyrroles AMERICAN CYANAMID COMPANY (US) 1995-01-03 US disclosed
US-5362746-A Process for the manufacture of insecticidal 2-aryl-1-(alkoxymethyl)-4-halo-5-(trifluoromethyl)pyrroles AMERICAN CYANAMID COMPANY (US) 1994-11-08 US disclosed
US-5302383-A For use in molluscicidal baits AMERICAN CYANAMID COMPANY (US) 1994-04-12 US disclosed
US-5286741-A N-oxy- and thioalkylcarbonyloxyalkylpyrrole insecticidal, acaricidal and molluscicidal agents AMERICAN CYANAMID COMPANY (US) 1994-02-15 US disclosed
US-5280021-A A sulfur containing pyrrole compound AMERICAN CYANAMID COMPANY (US) 1994-01-18 US disclosed
US-5254559-A Insecticidal, acaricidal and molluscicidal 1-(substituted)thioalkylpyrroles AMERICAN CYANAMID COMPANY (US) 1993-10-19 US disclosed
US-5232980-A Insecticides, miticides, molluscicides AMERICAN CYANAMID COMPANY (US) 1993-08-03 US disclosed
EP-0545103-A1 Insecticidal, acaricidal and molluscicidal 1-(substituted) thioalkylpyrroles AMERICAN CYANAMID COMPANY (US) 1993-06-09 EP disclosed
US-5194630-A Halogenation and etherification of 2-aryl-1-methyl-2-pyrroline AMERICAN CYANAMID COMPANY (US) 1993-03-16 US disclosed
EP-0530515-A1 N-Alkanoylaminomethyl and N-Aroylaminomethyl pyrrole insecticidal and acaricidal agents AMERICAN CYANAMID COMPANY (US) 1993-03-10 EP disclosed
US-5130328-A Lima bean leaves AMERICAN CYANAMID COMPANY (US) 1992-07-14 US disclosed
EP-0492171-A1 2-Aryl-5-trifluoromethyl)-2-pyrroline compounds and process for the manufacture of insecticidal, 2-aryl-1-(alkoxymethyl)-4-halo-5-(trofluoromethyl) pyrroles AMERICAN CYANAMID COMPANY (US) 1992-07-01 EP disclosed