SCHEMBL5819212

SCHEMBL5819212

COCn1c(-c2ccc(Cl)cc2)c(C#N)c(Br)c1C(F)(F)F

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 7/20 0.34
HPGD P15428 6/20 0.34
ALDH1A1 P00352 5/20 0.34
MEN1 O00255 4/20 0.34
KMT2A Q03164 4/20 0.34
HTT P42858 2/20 0.34
LMNA P02545 2/20 0.34
GAA P10253 2/20 0.34
GLA P06280 1/20 0.34
CRHBP P24387 1/20 0.34
CRHR2 Q13324 1/20 0.34
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
RXFP1 Q9HBX9 2/20 0.32
GRIA2 P42262 1/20 0.32
GRIA4 P48058 1/20 0.32
SQOR Q9Y6N5 1/20 0.32
POLB P06746 2/20 0.31
MAPT P10636 2/20 0.31
NPSR1 Q6W5P4 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Chlorfenapyr SCHEMBL40337 0.88 RXFP1 (0.35) KDM4EHPGDALDH1A1MEN1KMT2A
SCHEMBL5815133 0.88 KDM4E (0.36) KDM4EHPGDALDH1A1MEN1KMT2A
Chlorfenapyr SCHEMBL28530561 0.87 RXFP1 (0.35) KDM4EHPGDALDH1A1MEN1KMT2A
Chlorfenapyr SCHEMBL27488880 0.87 RXFP1 (0.35) KDM4EHPGDALDH1A1MEN1KMT2A
SCHEMBL28926283 0.86 KDM4E (0.32) KDM4EHPGDALDH1A1MEN1KMT2A
Chlorfenapyr SCHEMBL28508419 0.86 RXFP1 (0.36) KDM4EHPGDALDH1A1MEN1KMT2A
SCHEMBL27916628 0.86 KDM4E (0.33) KDM4EHPGDALDH1A1MEN1KMT2A
SCHEMBL9035868 0.86 ALDH1A1 (0.38) KDM4EHPGDALDH1A1MEN1KMT2A
SCHEMBL9301702 0.85 KDM4E (0.33) KDM4EHPGDALDH1A1MEN1KMT2A
SCHEMBL7508068 0.85 KDM4E (0.37) KDM4EHPGDALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0895839-B1 Arylpyrroles for the protection of wood, wood products and wood structures from insect attack BASF AG (DE) 2006-09-20 EP claimed
EP-0895717-B1 Arylpyrroles for subterranean termite control BASF AG (DE) 2003-05-28 EP claimed
EP-0895717-A1 Arylpyrroles for subterranean termite control American Cyanamid Company (US) 1999-02-10 EP claimed
EP-0895839-A1 Arylpyrroles for the protection of wood, wood products and wood structures from insect attack American Cyanamid Company (US) 1999-02-10 EP claimed
CN-115286551-A Preparation method of chlorfenapyr and analogue thereof 陕西美邦药业集团股份有限公司 2022-11-04 CN disclosed
EP-0895839-B1 Arylpyrroles for the protection of wood, wood products and wood structures from insect attack BASF AG (DE) 2006-09-20 EP disclosed
EP-0895717-B1 Arylpyrroles for subterranean termite control BASF AG (DE) 2003-05-28 EP disclosed
US-6077863-A TREATING WOOD OR WOOD PRODUCT OR SOIL SURROUNDED WITH ARYLPYRROLE INSECTICIDE, SPECIALLY TO KILL THE TERMITES AND CARPENTER ANTS AMERICAN CYANAMID COMPANY (US) 2000-06-20 US disclosed
US-6071951-A APPLYING SUBSTITUTED PYRROLE INSECTICIDES TO INFESTED SOILS OR ENVIRONMENTS AMERICAN CYANAMID COMPANY (US) 2000-06-06 US disclosed
EP-0895839-A1 Arylpyrroles for the protection of wood, wood products and wood structures from insect attack American Cyanamid Company (US) 1999-02-10 EP disclosed
EP-0895717-A1 Arylpyrroles for subterranean termite control American Cyanamid Company (US) 1999-02-10 EP disclosed
EP-0669318-B1 Alkoxymethylation of pyrroles to produce pesticides AMERICAN CYANAMID CO (US) 1998-07-15 EP disclosed
EP-0669318-A1 Alkoxymethylation of pyrroles to produce pesticides AMERICAN CYANAMID COMPANY (US) 1995-08-30 EP disclosed
US-5359090-A Reacting 1-H-pyrrole compound with dialkoxymethane in presence of vilsmeier reagent and a tertiary amine; useful as pesticidal, insecticidal, fungicidal, bactericidal, miticidal nematocidal and molluscicidal AMERICAN CYANAMID COMPANY (US) 1994-10-25 US disclosed