SCHEMBL7499419

SCHEMBL7499419

CCCCc1nc(C(=O)O)c(SCc2ccc(OC)cc2)n1Cc1cc2c(cc1Cl)OCO2

nearest known ligand 0.45

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
EDNRA P25101 2/20 0.45
BRS3 P32247 1/20 0.39
AGTR1 P30556 1/20 0.39
AGTR2 P50052 1/20 0.39
AURKA O14965 1/20 0.38
CSNK1E P49674 1/20 0.38
GSK3A P49840 1/20 0.38
GSK3B P49841 1/20 0.38
KDM4E B2RXH2 1/20 0.38
ALDH1A1 P00352 1/20 0.38
HPGD P15428 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
EDNRB P24530 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8432538 0.92 EDNRA (0.40) EDNRABRS3AGTR1AGTR2
SCHEMBL7499877 0.90 EDNRA (0.45) EDNRABRS3AGTR1AGTR2KDM4E
SCHEMBL7496916 0.88 EDNRA (0.54) EDNRABRS3AGTR1AGTR2EDNRB
SCHEMBL7499196 0.84 EDNRA (0.45) EDNRABRS3AGTR1AGTR2KDM4E
SCHEMBL8435078 0.82 EDNRA (0.47) EDNRABRS3AGTR1AGTR2SMN1; SMN2
SCHEMBL8433794 0.81 EDNRA (0.40) EDNRABRS3AGTR1AGTR2KDM4E
SCHEMBL7501757 0.81 EDNRA (0.55) EDNRABRS3EDNRB
SCHEMBL8664812 0.81 BRS3 (0.38) EDNRABRS3AURKACSNK1EGSK3A
SCHEMBL8434873 0.77 EDNRA (0.45) EDNRABRS3AURKACSNK1EGSK3A
SCHEMBL7501396 0.77 EDNRA (0.45) EDNRABRS3KDM4EALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0776325-B1 NOVEL USE AND NOVEL DERIVATIVES OF IMIDAZOLE, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AVENTIS PHARMA SA (FR) 2002-11-20 EP disclosed
US-5932741-A TREATING ILLNESSES RESULTING FROM ABNORMAL STIMULATION OF ENDOTHELIN RECEPTORS HOECHST MARION ROUSSEL (FR) 1999-08-03 US disclosed
US-5811444-A IMIDAZOLE DERIVATIVES ROUSSEL UCLAF (FR) 1998-09-22 US disclosed
EP-0776325-A1 NOVEL USE AND NOVEL DERIVATIVES OF IMIDAZOLE, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME ROUSSEL UCLAF (FR) 1997-06-04 EP disclosed
WO-1996004276-A1 NOVEL USE AND NOVEL DERIVATIVES OF IMIDAZOLE, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME ROUSSEL UCLAF (FR) 1996-02-15 WO disclosed