Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 14/20 | 0.58 |
| ▸ | CCR3 | P51677 | 14/20 | 0.58 |
| ▸ | CCR1 | P32246 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | DRD4 | P21917 | 4/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7512148 | 0.92 | HRH1 (0.57) | HRH1CCR3CCR1DRD2DRD4 | |
| SCHEMBL7513106 | 0.90 | DRD4 (0.50) | HRH1CCR3CCR1DRD2DRD4 | |
| SCHEMBL7510245 | 0.87 | DRD4 (0.51) | HRH1CCR3CCR1DRD2DRD4 | |
| SCHEMBL7507260 | 0.87 | CCR3 (0.54) | HRH1CCR3CCR1DRD2DRD4 | |
| SCHEMBL7508179 | 0.87 | HRH1 (0.63) | HRH1CCR3CCR1DRD2DRD4 | |
| SCHEMBL6213285 | 0.84 | HRH1 (0.60) | HRH1CCR3CCR1DRD2DRD4 | |
| SCHEMBL7512915 | 0.84 | DRD4 (0.57) | HRH1CCR3CCR1DRD2DRD4 | |
| SCHEMBL6214791 | 0.84 | HRH1 (0.58) | HRH1CCR3CCR1KCNH2 | |
| SCHEMBL6211818 | 0.83 | HRH1 (0.61) | HRH1CCR3CCR1KCNH2 | |
| SCHEMBL7511865 | 0.82 | DRD4 (0.49) | HRH1CCR3CCR1DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263725-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001062729-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2001-08-30 | — | — | WO | disclosed |