Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 6/20 | 0.49 |
| ▸ | DRD2 | P14416 | 4/20 | 0.49 |
| ▸ | DRD3 | P35462 | 3/20 | 0.49 |
| ▸ | CCR1 | P32246 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | CCR3 | P51677 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7069082 | 0.94 | DRD4 (0.56) | DRD4DRD2DRD3CCR1HRH1 | |
| SCHEMBL7513106 | 0.92 | DRD4 (0.50) | DRD4DRD2DRD3CCR1HRH1 | |
| SCHEMBL7511059 | 0.92 | DRD4 (0.50) | DRD4DRD2DRD3CCR1HRH1 | |
| SCHEMBL7512148 | 0.90 | HRH1 (0.57) | DRD4DRD2DRD3CCR1HRH1 | |
| SCHEMBL7509383 | 0.89 | DRD2 (0.45) | DRD4DRD2DRD3CCR1HRH1 | |
| SCHEMBL28750368 | 0.87 | DRD4 (0.49) | DRD4DRD2DRD3CCR1HRH1 | |
| SCHEMBL6216294 | 0.86 | CCR1 (0.47) | DRD4DRD2DRD3CCR1HRH1 | |
| SCHEMBL7512915 | 0.86 | DRD4 (0.57) | DRD4DRD2DRD3CCR1HRH1 | |
| SCHEMBL7508560 | 0.86 | DRD4 (0.57) | DRD4DRD2DRD3CCR1HRH1 | |
| SCHEMBL7508179 | 0.85 | HRH1 (0.63) | DRD4DRD2DRD3CCR1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263724-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001062728-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2001-08-30 | — | — | WO | disclosed |