Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | ACACA | Q13085 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27542726 | 0.80 | LMNA (0.43) | ACACBACACA | |
| SCHEMBL11041100 | 0.79 | — | — | |
| SCHEMBL5014042 | 0.79 | TRPV1 (0.50) | TRPV1TRPA1ALDH1A1MAPTTSHR | |
| SCHEMBL11384575 | 0.79 | TRPV1 (0.50) | TRPV1TRPA1ALDH1A1MAPTTSHR | |
| SCHEMBL5136481 | 0.79 | TRPV1 (0.50) | TRPV1TRPA1ALDH1A1MAPTTSHR | |
| SCHEMBL7757768 | 0.79 | TRPV1 (0.50) | TRPV1TRPA1ALDH1A1MAPTTSHR | |
| SCHEMBL5136479 | 0.79 | TRPV1 (0.50) | TRPV1TRPA1ALDH1A1MAPTTSHR | |
| SCHEMBL4443550 | 0.79 | TRPV1 (0.50) | TRPV1TRPA1ALDH1A1MAPTTSHR | |
| SCHEMBL17002461 | 0.79 | TRPV1 (0.50) | TRPV1TRPA1ALDH1A1MAPTTSHR | |
| SCHEMBL6285447 | 0.79 | TRPV1 (0.50) | TRPV1TRPA1ALDH1A1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9770429-B2 | 4-methylsulfonyl-2-butenenitrile and its pharmaceutical use | OLATEC THERAPEUTICS LLC (US) | 2017-09-26 | — | — | US | disclosed |
| US-20170231944-A1 | 4-METHYLSULFONYL-2-BUTENENITRILE AND ITS PHARMACEUTICAL USE | OLATEC THERAPEUTICS, INC. | 2017-08-17 | — | — | US | disclosed |
| US-9522878-B2 | 4-methylsulfonyl-2-butenenitrile and its pharmaceutical use | OLATEC THERAPEUTICS LLC (US) | 2016-12-20 | — | — | US | disclosed |
| EP-3055286-A1 | 4-METHYLSULFONYL-2-BUTENENITRILE AND ITS PHARMACEUTICAL USE | Olatec Therapeutics LLC (US) | 2016-08-17 | — | — | EP | disclosed |
| US-20160207881-A1 | 4-METHYLSULFONYL-2-BUTENENITRILE AND ITS PHARMACEUTICAL USE | OLATEC THERAPEUTICS, INC. | 2016-07-21 | — | — | US | disclosed |
| CN-105683158-A | 4-methylsulfonyl-2-butenenitrile and its pharmaceutical use | 欧拉泰克治疗有限责任公司 | 2016-06-15 | — | — | CN | disclosed |
| WO-2015054008-A1 | 4-METHYLSULFONYL-2-BUTENENITRILE AND ITS PHARMACEUTICAL USE | OLATEC INDUSTRIES LLC (US) | 2015-04-16 | — | — | WO | disclosed |
| EP-0757681-B1 | CONDENSED HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE AS GnRH ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-09-18 | — | — | EP | disclosed |
| US-5834463-A | CONTROLLING FERTILITY, MENSTRUAL CYCLES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-11-10 | — | — | US | disclosed |
| EP-0757681-A1 | CONDENSED HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE AS GnRH ANTAGONISTS | Takeda Chemical Industries, Ltd. (JP) | 1997-02-12 | — | — | EP | disclosed |
| WO-1995029900-A1 | CONDENSED HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE AS GnRH ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-11-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170231944-A1 | 4-METHYLSULFONYL-2-BUTENENITRILE AND ITS PHARMACEUTICAL USE | NFKBIA, SUCLG1, CUTA | ACACB 367/4885ACACA 513/4885TRPV1 598/4885 |
| US-20160207881-A1 | 4-METHYLSULFONYL-2-BUTENENITRILE AND ITS PHARMACEUTICAL USE | NFKBIA, SUCLG1, CUTA | ACACB 367/4885ACACA 513/4885TRPV1 598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.