Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8575364 | 0.71 | KCNH2 (0.46) | KCNH2CHRM1HTR1ACHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL7325637 | 0.71 | KCNH2 (0.45) | KCNH2CHRM1HTR1ACHRM2CHRM4 | |
| SCHEMBL9341414 | 0.69 | KCNH2 (0.48) | KCNH2DRD4HTR4 | |
| SCHEMBL7333317 | 0.69 | HTR4 (0.45) | KCNH2CHRM1HTR1ACHRM2CHRM4 | |
| SCHEMBL7346874 | 0.68 | KCNH2 (0.46) | KCNH2HTR4 | |
| SCHEMBL7346871 | 0.66 | KCNH2 (0.46) | KCNH2DRD4 | |
| SCHEMBL7383392 | 0.65 | KCNH2 (0.51) | KCNH2DRD4 | |
| SCHEMBL153896 | 0.65 | KCNH2 (0.88) | KCNH2 | |
| SCHEMBL9344322 | 0.65 | KCNH2 (0.48) | KCNH2DRD4HTR4 | |
| SCHEMBL11938940 | 0.64 | KCNH2 (0.55) | KCNH2HTR1AHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609278-A1 | IMIDAZOPYRIDINES AND INDOLIZINES AS 5-HT 4 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-08-10 | — | — | EP | disclosed |
| WO-1993008187-A1 | IMIDAZOPYRIDINES AND INDOLIZINES AS 5-HT4 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-04-29 | — | — | WO | disclosed |