Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.63 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.63 |
| ▸ | EGFR | P00533 | 14/20 | 0.62 |
| ▸ | ABL1 | P00519 | 2/20 | 0.62 |
| ▸ | ABL2 | P42684 | 2/20 | 0.62 |
| ▸ | PRKCA | P17252 | 1/20 | 0.62 |
| ▸ | GALR3 | O60755 | 1/20 | 0.52 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7496278 | 1.00 | ADORA2A (0.63) | ADORA2AADORA1EGFRABL1ABL2 | |
| SCHEMBL7496282 | 1.00 | ADORA2A (0.63) | ADORA2AADORA1EGFRABL1ABL2 | |
| SCHEMBL2461344 | 0.77 | EGFR (1.00) | EGFRABL1ABL2PRKCA | |
| SCHEMBL11105297 | 0.76 | GALR3 (0.60) | EGFRGALR3NR2F2LMNASMN1; SMN2 | |
| SCHEMBL22524381 | 0.75 | LMNA (0.54) | EGFRGALR3NR2F2LMNASMN1; SMN2 | |
| SCHEMBL22524379 | 0.75 | LMNA (0.54) | EGFRGALR3NR2F2LMNASMN1; SMN2 | |
| SCHEMBL16299046 | 0.74 | MAPK1 (0.63) | EGFRGALR3NR2F2LMNASMN1; SMN2 | |
| SCHEMBL11101615 | 0.74 | GALR3 (0.57) | EGFRGALR3NR2F2LMNASMN1; SMN2 | |
| SCHEMBL11104368 | 0.74 | GALR3 (0.57) | EGFRGALR3NR2F2LMNASMN1; SMN2 | |
| SCHEMBL8580389 | 0.73 | EGFR (0.55) | EGFRABL1PRKCAGALR3NR2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1100778-C | Pyrrolopyrimidines and process for their preparation | NOVARTIS CO (CH) | 2003-02-05 | — | — | CN | disclosed |
| EP-0836605-B1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2002-02-06 | — | — | EP | disclosed |
| US-6140332-A | Pyrrolopyrimidines and processes for the preparation thereof | NOVARTIS AG (CH) | 2000-10-31 | — | — | US | disclosed |
| CN-1194647-A | Pyrrolopyrimidines and processes for preparation thereof | NOVARTIS CO (CH) | 1998-09-30 | — | — | CN | disclosed |
| EP-0836605-A1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THE PREPARATION THEREOF | Novartis AG (CH) | 1998-04-22 | — | — | EP | disclosed |
| WO-1997002266-A1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 1997-01-23 | — | — | WO | disclosed |