Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 3/20 | 0.67 |
| ▸ | DRD2 | P14416 | 11/20 | 0.64 |
| ▸ | HTR1A | P08908 | 9/20 | 0.64 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | FAAH | O00519 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.52 |
| ▸ | BACE1 | P56817 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8138271 | 0.87 | DRD4 (0.62) | DRD4DRD2DRD3 | |
| SCHEMBL15937917 | 0.84 | DRD2 (0.69) | DRD4DRD2HTR1AHTR7DRD3 | |
| SCHEMBL7498385 | 0.84 | DRD2 (0.64) | DRD4DRD2HTR1AHTR7DRD3 | |
| SCHEMBL15937598 | 0.83 | DRD4 (0.67) | DRD4DRD2HTR1ADRD3 | |
| SCHEMBL15938505 | 0.83 | DRD4 (0.70) | DRD4DRD2HTR1AHTR7 | |
| SCHEMBL7505688 | 0.83 | DRD4 (0.54) | DRD4DRD2HTR1AFAAHBACE1 | |
| SCHEMBL7498001 | 0.82 | DRD4 (0.53) | DRD4DRD2HTR1AFAAHBACE1 | |
| SCHEMBL15938316 | 0.81 | DRD4 (0.67) | DRD4DRD2HTR1AHTR7 | |
| SCHEMBL7498974 | 0.81 | DRD4 (0.72) | DRD4DRD2HTR1AHTR7FAAH | |
| SCHEMBL7991732 | 0.80 | DRD4 (1.00) | DRD4DRD2HTR1AHTR7DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931067-B1 | D4 RECEPTOR SELECTIVITY PIPERAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2002-06-26 | — | — | EP | disclosed |
| US-6258813-B1 | BIOLOGICAL RECEPTORS WITH TETRAHYDROPIPERIZINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT (DE) | 2001-07-10 | — | — | US | disclosed |
| EP-0931067-A1 | D4 RECEPTOR SELECTIVITY PIPERAZINE DERIVATIVES | MERCK PATENT GmbH (DE) | 1999-07-28 | — | — | EP | disclosed |
| WO-1998011068-A1 | D4 RECEPTOR SELECTIVITY PIPERAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1998-03-19 | — | — | WO | disclosed |