Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 4/20 | 1.00 |
| ▸ | HTR7 | P34969 | 5/20 | 0.82 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | DRD2 | P14416 | 4/20 | 0.65 |
| ▸ | DRD3 | P35462 | 3/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | HTR1A | P08908 | 1/20 | 0.63 |
| ▸ | HRH2 | P25021 | 1/20 | 0.63 |
| ▸ | HRH1 | P35367 | 1/20 | 0.63 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.62 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12962319 | 0.95 | DRD4 (0.91) | DRD4HTR7POLBDRD2DRD3 | |
| Maleic Acid SCHEMBL7977396 | 0.91 | DRD4 (0.83) | DRD4HTR7POLBDRD2DRD3 | |
| Fumaric Acid SCHEMBL7977401 | 0.91 | DRD4 (0.83) | DRD4HTR7POLBDRD2DRD3 | |
| SCHEMBL15937972 | 0.90 | HTR7 (1.00) | DRD4HTR7POLBDRD2DRD3 | |
| SCHEMBL7991752 | 0.89 | DRD4 (0.79) | DRD4HTR7POLBDRD2DRD3 | |
| SCHEMBL9225440 | 0.88 | MAPK1 (0.81) | DRD4HTR7DRD2DRD3MAPK1 | |
| SCHEMBL15938315 | 0.88 | DRD2 (0.79) | DRD4HTR7DRD2DRD3HTR1A | |
| SCHEMBL15937822 | 0.87 | HTR7 (0.85) | DRD4HTR7POLBDRD2DRD3 | |
| SCHEMBL15938266 | 0.86 | HTR7 (0.83) | DRD4HTR7POLBDRD2DRD3 | |
| SCHEMBL15938805 | 0.86 | HTR7 (0.83) | DRD4HTR7POLBDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8883796-B2 | Biphenyl derivatives, pharmaceutical composition comprising the same, and preparation method thereof | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2014-11-11 | — | — | US | disclosed |
| US-20140228568-A1 | BIPHENYL DERIVATIVES, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND PREPARATION METHOD THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2014-08-14 | — | — | US | disclosed |
| US-20100009983-A1 | 5 HT RECEPTOR MEDIATED NEUROGENESIS | BRAINCELLS, INC. (US) | 2010-01-14 | — | — | US | disclosed |
| US-20100009983-A1 | 5 HT RECEPTOR MEDIATED NEUROGENESIS | BRAINCELLS, INC. (US) | 2010-01-14 | — | — | US | disclosed |
| US-6258813-B1 | BIOLOGICAL RECEPTORS WITH TETRAHYDROPIPERIZINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT (DE) | 2001-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009983-A1 | 5 HT RECEPTOR MEDIATED NEUROGENESIS | HTR6, GAP43, HTR5A | DRD4 301/4885HTR7 11/4885POLB 1896/4885 |
| US-20140228568-A1 | BIPHENYL DERIVATIVES, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND PREPARATION METHOD THEREOF | HTR7, HTR6, HTR3B | DRD4 210/4885HTR7 1/4885POLB 2005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.