Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTBP2 | P56545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.40 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11362876 | 0.76 | DGAT1 (0.54) | GSK3BALDH1A1DGAT1FFAR1 | |
| SCHEMBL11362878 | 0.76 | DGAT1 (0.54) | GSK3BALDH1A1DGAT1FFAR1 | |
| SCHEMBL335492 | 0.74 | CTBP2 (0.62) | CTBP2HTTGSK3BSAE1UBA2 | |
| SCHEMBL2578793 | 0.73 | NPC1 (0.48) | CTBP2HTTSAE1UBA2MAOA | |
| SCHEMBL2409822 | 0.72 | CTBP2 (0.56) | CTBP2HTTGSK3BSAE1UBA2 | |
| Hydrochloric Acid SCHEMBL7981327 | 0.72 | CTBP2 (0.61) | CTBP2HTTGSK3BSAE1UBA2 | |
| SCHEMBL29236556 | 0.72 | CTBP2 (0.61) | CTBP2HTTGSK3BSAE1UBA2 | |
| SCHEMBL6937899 | 0.72 | CTBP2 (0.59) | CTBP2HTTGSK3BSAE1UBA2 | |
| SCHEMBL6670974 | 0.71 | CTBP2 (0.64) | CTBP2HTTGSK3BSAE1UBA2 | |
| SCHEMBL16804596 | 0.70 | FFAR1 (0.68) | ALDH1A1MAOAKDM1AMAOBFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |