Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7500049 | 1.00 | SPHK1 (0.38) | SPHK1SMN1; SMN2BRD4HSD11B2 | |
| SCHEMBL21455156 | 0.81 | SPHK1 (0.43) | SPHK1BRD4HSD11B2 | |
| SCHEMBL20867962 | 0.81 | SPHK1 (0.43) | SPHK1BRD4HSD11B2 | |
| SCHEMBL21455299 | 0.81 | SPHK1 (0.43) | SPHK1BRD4HSD11B2 | |
| SCHEMBL7500045 | 0.76 | SPHK1 (0.39) | SPHK1SMN1; SMN2BRD4HSD11B2 | |
| SCHEMBL8445237 | 0.74 | SPHK1 (0.46) | SPHK1BRD4HSD11B2 | |
| SCHEMBL14357932 | 0.74 | SPHK1 (0.46) | SPHK1BRD4HSD11B2 | |
| SCHEMBL7504065 | 0.74 | HTT (0.41) | SPHK1SMN1; SMN2HSD11B2 | |
| SCHEMBL7499187 | 0.73 | SPHK1 (0.37) | SPHK1SMN1; SMN2BRD4 | |
| SCHEMBL6719410 | 0.73 | SPHK1 (0.37) | SPHK1SMN1; SMN2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1208097-A2 | SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS | Aventis Pharmaceuticals Inc. (US) | 2002-05-29 | — | — | EP | disclosed |
| WO-2001007436-A2 | SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS | AVENTIS PHARMACEUTICALS INC. (US) | 2001-02-01 | — | — | WO | disclosed |