Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT1 | P42224 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.65 |
| ▸ | HTT | P42858 | 5/20 | 0.61 |
| ▸ | RAF1 | P04049 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | PDE5A | O76074 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7502866 | 0.99 | STAT1 (0.66) | STAT1MAPK1HTTRAF1SMN1; SMN2 | |
| SCHEMBL7500245 | 0.90 | STAT1 (0.83) | STAT1MAPK1HTTRAF1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL27452405 | 0.88 | STAT1 (0.69) | STAT1MAPK1HTTRAF1SMN1; SMN2 | |
| SCHEMBL7496274 | 0.85 | PDE5A (0.63) | STAT1MAPK1HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL13192087 | 0.83 | MAPK1 (0.65) | STAT1MAPK1HTTRAF1SMN1; SMN2 | |
| SCHEMBL4778469 | 0.82 | MAPK1 (0.65) | STAT1MAPK1HTTRAF1SMN1; SMN2 | |
| SCHEMBL7497208 | 0.82 | STAT1 (0.61) | STAT1MAPK1HTTRAF1SMN1; SMN2 | |
| SCHEMBL7544551 | 0.82 | STAT1 (0.61) | STAT1MAPK1HTTRAF1SMN1; SMN2 | |
| SCHEMBL13192093 | 0.81 | EGFR (0.67) | MAPK1HTTSMN1; SMN2ALDH1A1PDE5A | |
| SCHEMBL9921508 | 0.80 | HTT (0.74) | MAPK1HTTSMN1; SMN2ALDH1A1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0607439-B1 | NITROGENOUS HETEROCYCLIC COMPOUND | EISAI CO LTD (JP) | 2002-01-09 | — | — | EP | disclosed |
| US-6046206-A | Method of treating a patient having a precancerous lesions with amide quinazoline derivatives | CELL PATHWAYS, INC. (US) | 2000-04-04 | — | — | US | disclosed |
| US-5801180-A | ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | EISAI CO., LTD. (JP) | 1998-09-01 | — | — | US | disclosed |
| US-5693652-A | Benzimidazoles for ischemic heart conditions | EISAI CO., LTD. (JP) | 1997-12-02 | — | — | US | disclosed |
| EP-0607439-A1 | NITROGENOUS HETEROCYCLIC COMPOUND | Eisai Co., Ltd. (JP) | 1994-07-27 | — | — | EP | disclosed |