Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.65 |
| ▸ | STAT1 | P42224 | 1/20 | 0.65 |
| ▸ | PDE5A | O76074 | 7/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 5/20 | 0.61 |
| ▸ | RAF1 | P04049 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7500245 | 0.88 | STAT1 (0.83) | MAPK1STAT1PDE5ALMNAHTT | |
| SCHEMBL4867391 | 0.84 | EGFR (0.67) | MAPK1STAT1PDE5ALMNAHTT | |
| Hydrochloric Acid SCHEMBL27452405 | 0.84 | STAT1 (0.69) | MAPK1STAT1PDE5AHTTRAF1 | |
| SCHEMBL7500128 | 0.83 | STAT1 (0.67) | MAPK1STAT1PDE5ALMNAHTT | |
| Hydrochloric Acid SCHEMBL7502866 | 0.82 | STAT1 (0.66) | MAPK1STAT1PDE5ALMNAHTT | |
| SCHEMBL9921508 | 0.81 | HTT (0.74) | MAPK1PDE5ALMNAHTTSMN1; SMN2 | |
| SCHEMBL7497715 | 0.79 | PDE5A (1.00) | PDE5A | |
| SCHEMBL13192081 | 0.79 | HTT (0.64) | MAPK1PDE5ALMNAHTTSMN1; SMN2 | |
| SCHEMBL7497208 | 0.79 | STAT1 (0.61) | MAPK1STAT1PDE5ALMNAHTT | |
| SCHEMBL7544551 | 0.79 | STAT1 (0.61) | MAPK1STAT1PDE5AHTTRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY (CN) | 2012-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | ATG7, BECN1, SQSTM1 | MAPK1 310/4885STAT1 2613/4885PDE5A 3288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.