Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.30 |
| ▸ | PTPRB | P23467 | 1/20 | 0.30 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9459194 | 0.72 | NPC1 (0.36) | NPC1MAPTPKMRAB9AALDH1A1 | |
| SCHEMBL7599608 | 0.69 | MAPT (0.54) | NPC1MAPTPKMRAB9AALDH1A1 | |
| SCHEMBL31316696 | 0.69 | MAPT (0.54) | NPC1MAPTPKMRAB9AALDH1A1 | |
| SCHEMBL2171598 | 0.66 | MAPT (0.50) | NPC1MAPTPKMRAB9AALDH1A1 | |
| SCHEMBL24193321 | 0.65 | MAPT (0.39) | NPC1MAPTPKMRAB9APOLB | |
| SCHEMBL12060932 | 0.65 | NPC1 (0.39) | NPC1MAPTPKMRAB9APTPN2 | |
| SCHEMBL31361549 | 0.65 | MAPT (0.39) | NPC1MAPTPKMRAB9APOLB | |
| SCHEMBL1105143 | 0.65 | NPC1 (0.39) | NPC1MAPTPKMRAB9AALDH1A1 | |
| SCHEMBL11919879 | 0.65 | NPC1 (0.39) | NPC1MAPTPKMRAB9APOLB | |
| SCHEMBL10656312 | 0.63 | KMT2A (0.31) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430014-A1 | ANTIVIRAL COMPOUNDS | Gilead Sciences, Inc. (US) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010132601-A1 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2010-11-18 | — | — | WO | disclosed |