Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 1/20 | 0.43 |
| ▸ | ABCC9 | O60706 | 6/20 | 0.42 |
| ▸ | ABCC8 | Q09428 | 6/20 | 0.42 |
| ▸ | KCNJ11 | Q14654 | 6/20 | 0.42 |
| ▸ | KCNJ8 | Q15842 | 6/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 7/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6641885 | 0.93 | ABCC9 (0.47) | VCAM1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL6643734 | 0.81 | BRD4 (0.47) | ABCC9ABCC8KCNJ11KCNJ8BRD4 | |
| SCHEMBL6643320 | 0.79 | ABCC9 (0.38) | VCAM1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7548646 | 0.78 | ABCC9 (0.44) | ABCC9ABCC8KCNJ11KCNJ8BRD4 | |
| SCHEMBL6649861 | 0.78 | ABCC9 (0.48) | VCAM1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7499328 | 0.78 | ABCC9 (0.43) | ABCC9ABCC8KCNJ11KCNJ8BRD4 | |
| SCHEMBL6856477 | 0.77 | ABCC9 (0.42) | VCAM1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL6928832 | 0.77 | ABCC9 (0.54) | ABCC9ABCC8KCNJ11KCNJ8MAPT | |
| SCHEMBL6643759 | 0.76 | ABCC9 (0.45) | ABCC9ABCC8KCNJ11KCNJ8BRD4 | |
| SCHEMBL6644997 | 0.73 | ABCC9 (0.49) | ABCC9ABCC8KCNJ11KCNJ8BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259510-A2 | TRICYCLIC DIHYDROPYRAZOLONE AND TRICYCLIC DIHYDROISOXAZOLONE POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-11-27 | — | — | EP | disclosed |
| WO-2001066544-A2 | TRICYCLIC DIHYDROPYRAZOLONE AND TRICYCLIC DIHYDROISOXAZOLONE POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2001-09-13 | — | — | WO | disclosed |