Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 19/20 | 0.43 |
| ▸ | KCNJ11 | Q14654 | 19/20 | 0.43 |
| ▸ | ABCC8 | Q09428 | 17/20 | 0.43 |
| ▸ | KCNJ8 | Q15842 | 17/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4255000 | 0.93 | ABCC9 (0.48) | ABCC9KCNJ11ABCC8KCNJ8BRD4 | |
| SCHEMBL7548646 | 0.90 | ABCC9 (0.44) | ABCC9KCNJ11ABCC8KCNJ8BRD4 | |
| SCHEMBL6649863 | 0.82 | ABCC9 (0.49) | ABCC9KCNJ11ABCC8KCNJ8BRD4 | |
| SCHEMBL6643887 | 0.81 | ABCC9 (0.62) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL6644712 | 0.81 | ABCC9 (0.57) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL6646960 | 0.80 | ABCC9 (0.46) | ABCC9KCNJ11ABCC8KCNJ8BRD4 | |
| SCHEMBL6644720 | 0.79 | ABCC9 (0.50) | ABCC9KCNJ11ABCC8KCNJ8BRD4 | |
| SCHEMBL7500218 | 0.78 | VCAM1 (0.43) | ABCC9KCNJ11ABCC8KCNJ8BRD4 | |
| SCHEMBL6849040 | 0.78 | ABCC9 (0.39) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL6852181 | 0.76 | ABCC9 (0.48) | ABCC9KCNJ11ABCC8KCNJ8BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259510-A2 | TRICYCLIC DIHYDROPYRAZOLONE AND TRICYCLIC DIHYDROISOXAZOLONE POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-11-27 | — | — | EP | disclosed |
| WO-2001066544-A2 | TRICYCLIC DIHYDROPYRAZOLONE AND TRICYCLIC DIHYDROISOXAZOLONE POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2001-09-13 | — | — | WO | disclosed |