SCHEMBL7500441

SCHEMBL7500441

NS(=O)(=O)c1ccc(-c2oc(COc3ccccc3F)nc2-c2ccccc2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 10/20 0.51
PTGS1 P23219 3/20 0.51
CA1 P00915 4/20 0.44
CA2 P00918 4/20 0.44
CA12 O43570 2/20 0.44
CA9 Q16790 2/20 0.44
NR4A2 P43354 4/20 0.43
NR4A1 P22736 2/20 0.43
NR4A3 Q92570 2/20 0.43
PPARD Q03181 1/20 0.42
CYP3A4 P08684 2/20 0.42
CYP2C19 P33261 2/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
MAOA P21397 1/20 0.41
MAOB P27338 1/20 0.41
KDM4E B2RXH2 1/20 0.41
ABCC4 O15439 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7502967 1.00 PTGS2 (0.51) PTGS2PTGS1CA1CA2CA12
SCHEMBL8549353 0.90 PTGS2 (0.52) PTGS2PTGS1CA1CA2CA12
SCHEMBL7500598 0.89 PTGS2 (0.56) PTGS2PTGS1NR4A2NR4A1NR4A3
SCHEMBL7502840 0.89 PTGS2 (0.56) PTGS2PTGS1NR4A2NR4A1NR4A3
SCHEMBL7510284 0.87 PTGS2 (0.57) PTGS2PTGS1CA1CA2CA12
SCHEMBL7502663 0.87 PTGS2 (0.57) PTGS2PTGS1CA1CA2CA12
SCHEMBL7506180 0.87 RORC (0.48) PTGS2PTGS1CA1CA2CA12
SCHEMBL7498119 0.87 RORC (0.48) PTGS2PTGS1CA1CA2CA12
SCHEMBL7501777 0.86 PTGS2 (0.58) PTGS2PTGS1CA1CA2CA12
SCHEMBL7506158 0.85 CA1 (0.56) PTGS2PTGS1CA1CA2CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0699192-B1 SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION SEARLE & CO (US) 2002-07-24 EP disclosed
US-6090834-A ANALGESICS; RHEUMATIC DISORDERS; SKIN DISORDERS; GASTROINTESTINAL DISORDERS G.D. SEARLE & CO. (US) 2000-07-18 US disclosed
WO-1996036617-A1 SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1996-11-21 WO disclosed
EP-0699192-A1 SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1996-03-06 EP disclosed
WO-1994027980-A1 SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1994-12-08 WO disclosed