Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 17/20 | 0.46 |
| ▸ | HTR2C | P28335 | 17/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.46 |
| ▸ | DRD2 | P14416 | 6/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7497311 | 0.90 | CNR1 (0.42) | HTR2AHTR2CKCNH2DRD2HRH3 | |
| SCHEMBL7501576 | 0.87 | KCNH2 (0.49) | HTR2AHTR2CKCNH2DRD2HRH3 | |
| SCHEMBL7031992 | 0.83 | HTR2A (0.59) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL7031347 | 0.82 | HTR2A (0.51) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL7031635 | 0.75 | HTR2A (0.57) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL7033473 | 0.74 | KCNH2 (0.48) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL7027370 | 0.73 | CARM1 (0.48) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL7024620 | 0.73 | P2RX7 (0.46) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL7028390 | 0.72 | HTR2A (0.54) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL7030766 | 0.72 | HTR2A (0.54) | HTR2AHTR2CKCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246803-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES WHICH FUNCTION AS 5-HT 2A? RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001051469-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES WHICH FUNCTION AS 5-HT2A RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2001-07-19 | — | — | WO | disclosed |