Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | CHKA | P35790 | 2/20 | 0.43 |
| ▸ | PRCP | P42785 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7500742 | 0.87 | HTR2A (0.46) | KCNH2HRH3HTR2AHTR2CDRD2 | |
| SCHEMBL7497311 | 0.85 | CNR1 (0.42) | KCNH2HRH3CHKAHTR2AHTR2C | |
| SCHEMBL7026680 | 0.81 | HTR2A (0.55) | KCNH2HTR2AHTR2CHTR7HTR6 | |
| SCHEMBL7027681 | 0.81 | HTR2A (0.49) | KCNH2PRCPHTR2AHTR2CHTR7 | |
| SCHEMBL7028334 | 0.80 | MEN1 (0.43) | KCNH2HRH3PRCPHTR2AHTR2C | |
| SCHEMBL7027762 | 0.78 | HTR2A (0.49) | HRH3HTR2AHTR2CHTR7HTR6 | |
| SCHEMBL7032512 | 0.78 | CARM1 (0.57) | HTR2AHTR2CHTR7HTR6 | |
| SCHEMBL7028399 | 0.78 | PRCP (0.50) | KCNH2PRCPHTR2AHTR2CHTR7 | |
| SCHEMBL7106789 | 0.77 | RAB9A (0.55) | KCNH2PRCPHTR2AHTR2CHTR7 | |
| SCHEMBL7029891 | 0.76 | HTR2A (0.50) | HTR2AHTR2CHTR7HTR6HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246803-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES WHICH FUNCTION AS 5-HT 2A? RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001051469-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES WHICH FUNCTION AS 5-HT2A RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2001-07-19 | — | — | WO | disclosed |