Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 4/20 | 0.35 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7664526 | 0.83 | CXCR2 (0.39) | CXCR2CXCR1KMT2ACA1CA2 | |
| SCHEMBL6550852 | 0.82 | CXCR2 (0.41) | CXCR2CXCR1CA1CA2 | |
| SCHEMBL27608152 | 0.78 | CXCR2 (0.51) | CXCR2CXCR1CA1CA2 | |
| SCHEMBL4587656 | 0.76 | CXCR2 (0.62) | CXCR2CXCR1 | |
| SCHEMBL7112805 | 0.76 | ESR1 (0.36) | LMNAPKMCXCR2CXCR1KMT2A | |
| SCHEMBL7500207 | 0.75 | MAPT (0.44) | LMNAPKMCXCR2CXCR1KMT2A | |
| SCHEMBL7663605 | 0.75 | KMT2A (0.40) | LMNAPKMCXCR2KMT2ACA1 | |
| SCHEMBL6565796 | 0.74 | LMNA (0.40) | LMNAPKMCXCR2KMT2AFABP4 | |
| SCHEMBL27552285 | 0.74 | CXCR2 (0.40) | LMNACXCR2KMT2AALDH1A1 | |
| SCHEMBL7666870 | 0.73 | CXCR1 (0.39) | CXCR2CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161232-A4 | HYDROXY DIPHENYL UREA SULFONAMIDES AS IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-09-18 | — | — | EP | disclosed |
| EP-1161232-A1 | HYDROXY DIPHENYL UREA SULFONAMIDES AS IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000035442-A1 | HYDROXY DIPHENYL UREA SULFONAMIDES AS IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-06-22 | — | — | WO | disclosed |