Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 5/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7507707 | 0.84 | SLC1A3 (0.38) | CXCR2KMT2AMEN1POLBGAA | |
| SCHEMBL27552285 | 0.84 | CXCR2 (0.40) | CXCR2KMT2ALMNAALDH1A1RORC | |
| SCHEMBL7663605 | 0.83 | KMT2A (0.40) | ESR1CXCR2KMT2AMEN1POLB | |
| SCHEMBL7500704 | 0.78 | CXCR2 (0.47) | CXCR2KMT2APOLBGAAHTT | |
| SCHEMBL6550852 | 0.77 | CXCR2 (0.41) | ESR1CXCR2CXCR1CX3CR1 | |
| SCHEMBL7500837 | 0.76 | LMNA (0.37) | CXCR2KMT2ALMNAALDH1A1CXCR1 | |
| SCHEMBL28941368 | 0.76 | CXCR2 (0.38) | CXCR2KMT2ALMNAALDH1A1PKM | |
| SCHEMBL7118983 | 0.76 | CXCR2 (0.43) | CXCR2KMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL27571719 | 0.76 | CXCR2 (0.43) | CXCR2LMNAALDH1A1PKMCX3CR1 | |
| SCHEMBL7664526 | 0.75 | CXCR2 (0.39) | CXCR2KMT2AALDH1A1CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030109527-A1 | Hydroxy diphenyl urea sulfonamides as IL-8 receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 2003-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030109527-A1 | Hydroxy diphenyl urea sulfonamides as IL-8 receptor antagonists | CXCL8, CCR8, IL18 | ESR1 2110/4885CXCR2 26/4885VCAM1 702/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.