Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7026165 | 0.80 | KCNH2 (0.69) | HTR2AHTR2CKCNH2MEN1KMT2A | |
| SCHEMBL7027668 | 0.79 | FABP1 (0.65) | HTR2AHTR2CPKMMAPT | |
| SCHEMBL6251264 | 0.77 | PRKAA2 (0.56) | HTR2AHTR2CKCNH2MEN1KMT2A | |
| SCHEMBL7024144 | 0.77 | KCNH2 (0.53) | HTR2AHTR2CKCNH2MEN1KMT2A | |
| SCHEMBL7027186 | 0.75 | KMT2A (0.68) | MEN1KMT2APKMKDM4ELMNA | |
| SCHEMBL7024946 | 0.74 | KCNH2 (0.53) | HTR2AHTR2CKCNH2MEN1KMT2A | |
| SCHEMBL31454317 | 0.74 | KCNH2 (0.55) | HTR2AHTR2CKCNH2MEN1KMT2A | |
| SCHEMBL7501576 | 0.74 | KCNH2 (0.49) | HTR2AHTR2CKCNH2HTR1AHTR7 | |
| SCHEMBL16087283 | 0.74 | L3MBTL1 (0.63) | MEN1KMT2APKMMAPTLMNA | |
| SCHEMBL7551148 | 0.72 | HTR2A (0.57) | HTR2AHTR2CKCNH2CHRM5HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246803-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES WHICH FUNCTION AS 5-HT 2A? RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 2002-10-09 | — | — | EP | claimed |
| WO-2001051469-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES WHICH FUNCTION AS 5-HT2A RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2001-07-19 | — | — | WO | claimed |
| EP-1246803-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES WHICH FUNCTION AS 5-HT 2A? RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001051469-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES WHICH FUNCTION AS 5-HT2A RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2001-07-19 | — | — | WO | disclosed |