Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRB1 | P17538 | 1/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CTRC | Q99895 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7991029 | 1.00 | CTRB1 (0.46) | CTRB1DDB1CRBNHCAR2CFTR | |
| SCHEMBL6844052 | 1.00 | CTRB1 (0.46) | CTRB1DDB1CRBNHCAR2CFTR | |
| SCHEMBL7971330 | 0.84 | CTRB1 (0.42) | CTRB1DDB1CRBNCFTRGOPC | |
| SCHEMBL7973421 | 0.80 | CYP19A1 (0.39) | HCAR2TP53CYP19A1POLB | |
| SCHEMBL7969548 | 0.77 | CYP19A1 (0.45) | CYP19A1POLBMEN1KMT2A | |
| SCHEMBL7988000 | 0.76 | POLB (0.42) | HCAR2POLBMEN1KMT2A | |
| SCHEMBL6844067 | 0.76 | POLB (0.42) | HCAR2POLBMEN1KMT2A | |
| SCHEMBL11548049 | 0.75 | DDB1 (0.47) | CTRB1DDB1CRBNCFTRGOPC | |
| SCHEMBL3534373 | 0.75 | DDB1 (0.47) | CTRB1DDB1CRBNCFTRGOPC | |
| SCHEMBL8111417 | 0.74 | IDO1 (0.48) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291679-B1 | REACTING 3-OXO-6-PHENYLCYCLOHEX-1-ENE-1-CARBOXYLATE WITH ENZYME FORMING OPTICAL ISOMER; TREATING WITH AMINE PROTECTED N-TRIALKYLSILYLMETHYL-N-(ALKOXYMETHYL)AMINE TO FORM PHENYLPERHYDROISOINDOLE-3A-CARBOXYLATE DERIVATIVE, CYCLIZATION | RHONE-POULENC RORER S.A. (FR) | 2001-09-18 | — | — | US | disclosed |
| US-6218406-B1 | AS ANTITUMOR AND ANTILEUKEMIC AGENTS | AVENTIS PHARMA S.A. (FR) | 2001-04-17 | — | — | US | disclosed |
| US-6124465-A | Farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments | RHONE-POULENC S.A. (FR) | 2000-09-26 | — | — | US | disclosed |
| US-6013662-A | ANTITUMOR, ANTICARCINOGENIC AGENTS | RHONE-POULENC RORER S.A. (FR) | 2000-01-11 | — | — | US | disclosed |