Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 15/20 | 0.43 |
| ▸ | ITGAV | P06756 | 15/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 15/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.43 |
| ▸ | ITGB5 | P18084 | 4/20 | 0.43 |
| ▸ | CCR8 | P51685 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7501198 | 0.85 | PKM (0.48) | PKMITGB3ITGAVITGA2BITGB1 | |
| SCHEMBL7502056 | 0.83 | ITGB3 (0.53) | PKMITGB3ITGAVITGA2BITGB1 | |
| SCHEMBL7495919 | 0.81 | ITGB3 (0.49) | PKMITGB3ITGAVITGA2BITGB1 | |
| SCHEMBL7500866 | 0.80 | ITGB3 (0.67) | PKMITGB3ITGAVITGA2BITGB1 | |
| SCHEMBL7499421 | 0.80 | ITGB3 (0.67) | PKMITGB3ITGAVITGA2BITGB1 | |
| SCHEMBL7501345 | 0.80 | ITGB3 (0.67) | PKMITGB3ITGAVITGA2BITGB1 | |
| SCHEMBL7502143 | 0.80 | ITGB3 (0.66) | PKMITGB3ITGAVITGA2BITGB1 | |
| SCHEMBL7500563 | 0.80 | ITGB3 (0.66) | PKMITGB3ITGAVITGA2BITGB1 | |
| SCHEMBL7500879 | 0.80 | ITGB3 (0.66) | PKMITGB3ITGAVITGA2BITGB1 | |
| SCHEMBL8441149 | 0.79 | PKM (0.47) | PKMITGB3ITGAVITGA2BITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894084-B1 | CINNAMIC ACID DERIVATIVES AND THEIR USE AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2002-06-26 | — | — | EP | claimed |
| EP-0894084-A1 | CINNAMIC ACID DERIVATIVES AND THEIR USE AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-02-03 | — | — | EP | claimed |
| WO-1997036860-A1 | CINNAMIC ACID DERIVATIVES AND THEIR USE AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |
| EP-0894084-B1 | CINNAMIC ACID DERIVATIVES AND THEIR USE AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2002-06-26 | — | — | EP | disclosed |
| EP-0894084-A1 | CINNAMIC ACID DERIVATIVES AND THEIR USE AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-02-03 | — | — | EP | disclosed |
| WO-1997036860-A1 | CINNAMIC ACID DERIVATIVES AND THEIR USE AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | disclosed |