SCHEMBL7501211

SCHEMBL7501211

CSc1ccc2c(C(=O)C(=O)Cl)cn(C)c2c1

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.39
KMT2A Q03164 2/20 0.39
LMNA P02545 2/20 0.39
MITF O75030 1/20 0.39
MAPT P10636 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
MAP2K2 P36507 1/20 0.38
MAP2K1 Q02750 1/20 0.38
MCL1 Q07820 1/20 0.37
NR4A2 P43354 1/20 0.37
POLB P06746 1/20 0.37
RAB9A P51151 3/20 0.36
NPC1 O15118 2/20 0.36
MEN1 O00255 1/20 0.36
HTT P42858 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7500735 0.83 ALDH1A1 (0.42) ALDH1A1KMT2ALMNAMITFMAPT
SCHEMBL7502009 0.82 KMT2A (0.41) ALDH1A1KMT2ALMNAMITFMAPT
SCHEMBL7504662 0.81 KMT2A (0.40) ALDH1A1KMT2ALMNAMITFMAPT
SCHEMBL7506054 0.81 IDO1 (0.46) ALDH1A1KMT2ALMNAMITFMAPT
SCHEMBL7501910 0.81 ALDH1A1 (0.40) ALDH1A1KMT2ALMNAMITFMAPT
SCHEMBL7503200 0.78 ALDH1A1 (0.54) ALDH1A1KMT2ASMN1; SMN2NR4A2MEN1
SCHEMBL7501684 0.77 IMPDH2 (0.41) ALDH1A1KMT2ALMNAMITFMAPT
SCHEMBL461911 0.76 ALDH1A1 (0.64) ALDH1A1KMT2ALMNAMITFMAPT
SCHEMBL7505867 0.76 NR4A2 (0.50) ALDH1A1KMT2ALMNAMAPTNPSR1
SCHEMBL7494198 0.76 SMN1; SMN2 (0.47) ALDH1A1KMT2ALMNAMITFMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0915870-B1 SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION HOFFMANN LA ROCHE (CH) 2002-09-25 EP disclosed
US-6228877-B1 ANTICARCINOGENIC, ANTITUMOR AND ANTIPROLIFERATIVE AGENTS HOFFMANN-LA ROCHE INC. 2001-05-08 US disclosed
EP-0915870-A1 SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION F. HOFFMANN-LA ROCHE AG (CH) 1999-05-19 EP disclosed
EP-0915871-A1 SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION F. HOFFMANN-LA ROCHE AG (CH) 1999-05-19 EP disclosed
US-5891901-A ANTICARCINOGENIC AGENTS OR ANTITUMOR AGENTS HOFFMANN-LA ROCHE INC. (US) 1999-04-06 US disclosed
WO-1998004553-A1 SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION F.HOFFMANN-LA ROCHE AG (CH) 1998-02-05 WO disclosed
WO-1998004551-A1 SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION F. HOFFMANN-LA ROCHE AG (CH) 1998-02-05 WO disclosed