Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.88 |
| ▸ | DRD4 | P21917 | 12/20 | 0.88 |
| ▸ | DRD3 | P35462 | 12/20 | 0.88 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | HTR1A | P08908 | 3/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.56 |
| ▸ | HTR7 | P34969 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | DRD5 | P21918 | 1/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | LSS | P48449 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7977347 | 0.98 | DRD2 (0.84) | DRD2DRD4DRD3MAPTHTR1A | |
| SCHEMBL7503673 | 0.94 | DRD2 (1.00) | DRD2DRD4DRD3MAPTHTR1A | |
| Hydrochloric Acid SCHEMBL27429088 | 0.93 | DRD2 (0.97) | DRD2DRD4DRD3MAPTHTR1A | |
| Hydrochloric Acid SCHEMBL7977304 | 0.93 | DRD2 (0.97) | DRD2DRD4DRD3MAPTHTR1A | |
| SCHEMBL7496912 | 0.88 | DRD4 (0.88) | DRD2DRD4DRD3MAPTHTR1A | |
| SCHEMBL7503409 | 0.88 | DRD2 (1.00) | DRD2DRD4DRD3HTR1AHTR2A | |
| Hydrochloric Acid SCHEMBL7991606 | 0.86 | DRD2 (0.95) | DRD2DRD4DRD3HTR1AHTR2A | |
| SCHEMBL7502147 | 0.85 | DRD2 (0.82) | DRD2DRD4DRD3MAPTHTR1A | |
| SCHEMBL7977385 | 0.85 | DRD2 (0.74) | DRD2DRD4DRD3MAPTHTR1A | |
| SCHEMBL7506832 | 0.85 | DRD2 (0.73) | DRD2DRD4DRD3MAPTHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1114594-C | D4 receptor selectivity piperazine derivatives | MERCK PATENT GMBH (DE) | 2003-07-16 | — | — | CN | claimed |
| EP-0931067-B1 | D4 RECEPTOR SELECTIVITY PIPERAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2002-06-26 | — | — | EP | claimed |
| US-6258813-B1 | BIOLOGICAL RECEPTORS WITH TETRAHYDROPIPERIZINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT (DE) | 2001-07-10 | — | — | US | claimed |
| EP-0931067-B1 | D4 RECEPTOR SELECTIVITY PIPERAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2002-06-26 | — | — | EP | disclosed |
| EP-0931067-A1 | D4 RECEPTOR SELECTIVITY PIPERAZINE DERIVATIVES | MERCK PATENT GmbH (DE) | 1999-07-28 | — | — | EP | disclosed |
| WO-1998011068-A1 | D4 RECEPTOR SELECTIVITY PIPERAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1998-03-19 | — | — | WO | disclosed |