SCHEMBL7502147

SCHEMBL7502147

COc1ccc(N2CCN(Cc3cncc(-c4ccc(F)cc4)c3)CC2)cc1

nearest known ligand 0.82

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 9/20 0.82
DRD4 P21917 8/20 0.82
DRD3 P35462 8/20 0.82
MAPT P10636 2/20 0.61
L3MBTL1 Q9Y468 2/20 0.61
LMNA P02545 1/20 0.61
SMO Q99835 2/20 0.53
HTR1A P08908 2/20 0.53
HTR2A P28223 1/20 0.53
HTR7 P34969 1/20 0.53
HTR2B P41595 1/20 0.53
KDM4E B2RXH2 2/20 0.50
ALDH1A1 P00352 2/20 0.49
GFER P55789 1/20 0.49
PKM P14618 1/20 0.48
TGFBR1 P36897 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7977823 0.99 DRD2 (0.80) DRD2DRD4DRD3MAPTL3MBTL1
SCHEMBL7503673 0.91 DRD2 (1.00) DRD2DRD4DRD3MAPTL3MBTL1
Hydrochloric Acid SCHEMBL27429088 0.90 DRD2 (0.97) DRD2DRD4DRD3MAPTL3MBTL1
Hydrochloric Acid SCHEMBL7977304 0.90 DRD2 (0.97) DRD2DRD4DRD3MAPTL3MBTL1
SCHEMBL7496998 0.89 DRD2 (0.74) DRD2DRD4DRD3MAPTL3MBTL1
Hydrochloric Acid SCHEMBL7988088 0.88 DRD2 (0.72) DRD2DRD4DRD3MAPTL3MBTL1
SCHEMBL7495085 0.87 DRD2 (0.75) DRD2DRD4DRD3MAPTL3MBTL1
Hydrochloric Acid SCHEMBL7989565 0.86 DRD2 (0.73) DRD2DRD4DRD3MAPTL3MBTL1
SCHEMBL7496912 0.85 DRD4 (0.88) DRD2DRD4DRD3MAPTHTR1A
SCHEMBL7501372 0.85 DRD2 (0.88) DRD2DRD4DRD3MAPTHTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0931067-B1 D4 RECEPTOR SELECTIVITY PIPERAZINE DERIVATIVES MERCK PATENT GMBH (DE) 2002-06-26 EP disclosed
US-6258813-B1 BIOLOGICAL RECEPTORS WITH TETRAHYDROPIPERIZINE DERIVATIVES MERCK PATENT GESELLSCHAFT MIT (DE) 2001-07-10 US disclosed
EP-0931067-A1 D4 RECEPTOR SELECTIVITY PIPERAZINE DERIVATIVES MERCK PATENT GmbH (DE) 1999-07-28 EP disclosed
WO-1998011068-A1 D4 RECEPTOR SELECTIVITY PIPERAZINE DERIVATIVES MERCK PATENT GMBH (DE) 1998-03-19 WO disclosed