Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 8/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 8/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6760059 | 0.79 | RPS6KA5 (0.56) | MKNK1MKNK2HTTRPS6KA5FGFR1 | |
| SCHEMBL2899962 | 0.78 | HTT (0.55) | MKNK1MKNK2HTTFGFR1PIK3CB | |
| SCHEMBL9025863 | 0.75 | PIK3CB (0.68) | MKNK1MKNK2HTTFGFR1PIK3CB | |
| SCHEMBL6628644 | 0.73 | LCK (0.57) | MKNK1MKNK2HTTRPS6KA5FGFR1 | |
| SCHEMBL19350753 | 0.71 | MKNK1 (0.59) | MKNK1MKNK2HTTFGFR1PIK3CB | |
| SCHEMBL2465676 | 0.70 | MKNK2 (0.67) | MKNK1MKNK2HTTRPS6KA5FGFR1 | |
| SCHEMBL24179153 | 0.70 | FGFR1 (0.51) | HTTFGFR1POLB | |
| SCHEMBL5937 | 0.69 | HTT (0.56) | MKNK1MKNK2HTTFGFR1POLB | |
| SCHEMBL22188457 | 0.69 | HTT (0.56) | MKNK1MKNK2HTTFGFR1POLB | |
| SCHEMBL7211112 | 0.69 | HTT (0.56) | HTTFGFR1POLBROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194152-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-11-06 | — | — | EP | disclosed |
| EP-1194152-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-04-10 | — | — | EP | disclosed |
| US-6316444-B1 | SRC kinase inhibitor compounds | MERCK & CO., INC. | 2001-11-13 | — | — | US | disclosed |
| WO-2001000214-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |