SCHEMBL2899962

SCHEMBL2899962

Brc1cnc(-n2cnc3ccccc32)nc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 2/20 0.55
MKNK1 Q9BUB5 1/20 0.51
MKNK2 Q9HBH9 1/20 0.51
POLB P06746 1/20 0.50
FGFR1 P11362 4/20 0.49
PIK3CB P42338 1/20 0.48
ROCK1 Q13464 1/20 0.44
TUBB4A P04350 1/20 0.44
TUBB P07437 1/20 0.44
TUBA3C P0DPH7 1/20 0.44
TUBA1B P68363 1/20 0.44
TUBA4A P68366 1/20 0.44
TUBB4B P68371 1/20 0.44
TUBB3 Q13509 1/20 0.44
TUBB2A Q13885 1/20 0.44
TUBB8 Q3ZCM7 1/20 0.44
TUBA3E Q6PEY2 1/20 0.44
TUBA1A Q71U36 1/20 0.44
TUBA1C Q9BQE3 1/20 0.44
TUBB6 Q9BUF5 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19350753 0.82 MKNK1 (0.59) HTTMKNK1MKNK2POLBFGFR1
SCHEMBL2465676 0.81 MKNK2 (0.67) HTTMKNK1MKNK2POLBFGFR1
Hydrochloric Acid SCHEMBL2491050 0.79 MKNK2 (0.65) HTTMKNK1MKNK2POLBFGFR1
SCHEMBL9025863 0.79 PIK3CB (0.68) HTTMKNK1MKNK2POLBFGFR1
SCHEMBL1431824 0.78 HTT (0.58) HTTMKNK1MKNK2POLBFGFR1
SCHEMBL7501389 0.78 MKNK1 (0.51) HTTMKNK1MKNK2POLBFGFR1
SCHEMBL3496264 0.76 HTT (0.72) HTTFGFR1
SCHEMBL19350754 0.76 FGFR1 (0.62) HTTMKNK1MKNK2FGFR1
SCHEMBL29623800 0.76 FGFR1 (0.62) HTTMKNK1MKNK2FGFR1
SCHEMBL23243817 0.75 HTT (0.65) HTTPOLBFGFR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100286211-A1 OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS RANBAXY LABORATORIES LIMITED (IN) 2010-11-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100286211-A1 OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS OXA1L, PDK4, MLYCD HTT 2211/4885MKNK1 1509/4885MKNK2 2363/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.