Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | BCL9 | O00512 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7497620 | 0.85 | PTGS1 (0.55) | PTGS2PTGS1ESR1HSP90AA1 | |
| SCHEMBL7501526 | 0.81 | PTGS2 (0.51) | PTGS2PTGS1ESR1ESR2 | |
| SCHEMBL7498396 | 0.80 | PTGS2 (0.50) | PTGS2PTGS1ESR1PTGDR2 | |
| SCHEMBL7498185 | 0.79 | PTGS2 (0.62) | PTGS2PTGS1ESR1PTGDR2 | |
| SCHEMBL7499348 | 0.79 | PTGS2 (0.58) | PTGS2PTGS1ESR1PTGDR2 | |
| SCHEMBL7506942 | 0.76 | ALDH1A1 (0.47) | PTGDR2 | |
| SCHEMBL7505272 | 0.75 | MEN1 (0.47) | PTGS2PTGS1HSP90AA1 | |
| SCHEMBL7499994 | 0.75 | PTGS2 (0.54) | PTGS2PTGS1ESR1 | |
| SCHEMBL7507961 | 0.75 | PTGS1 (0.43) | PTGS2PTGS1HSP90AA1 | |
| SCHEMBL7503730 | 0.74 | PTGS2 (0.47) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966437-B1 | 5-AROYLNAPHTHALENE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2002-06-12 | — | — | EP | disclosed |
| US-6150397-A | 5-(PYRIDYL, FURYL, OR THIENYL SUBSTITUTED)-6-SUBSTITUTED-2--2-NAPHTHALENESULFONAMIDES OF GIVEN FORMULA; INHIBITORS OF PROSTAGLANDIN G/H SYNTHASE; TREATING INFLAMMATORY DISEASE SUCH AS GOUT, ARTHRITIS, MYOSITIS, SYNOVITIS | SYNTEX (U.S.A.) INC. (US) | 2000-11-21 | — | — | US | disclosed |
| EP-0966437-A1 | 5-AROYLNAPHTHALENE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1999-12-29 | — | — | EP | disclosed |
| US-5962531-A | PROSTAGLANDIN SYNTHASE INHIBITOR; RHEUMATIC DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1999-10-05 | — | — | US | disclosed |
| WO-1998032732-A1 | 5-AROYLNAPHTHALENE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1998-07-30 | — | — | WO | disclosed |