Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.63 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.63 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.63 |
| ▸ | GLA | P06280 | 3/20 | 0.63 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.61 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6250197 | 0.90 | MEN1 (0.87) | MEN1KMT2AKDM4EADORA2AADORA1 | |
| SCHEMBL7553240 | 0.85 | KDM4E (0.76) | MEN1KMT2AKDM4EADORA2AADORA1 | |
| SCHEMBL6252557 | 0.85 | KMT2A (0.79) | MEN1KMT2AKDM4EADORA2AADORA1 | |
| SCHEMBL31120373 | 0.85 | KMT2A (0.79) | MEN1KMT2AKDM4EADORA2AADORA1 | |
| SCHEMBL7501358 | 0.81 | MEN1 (0.70) | MEN1KMT2AKDM4EADORA2AADORA1 | |
| SCHEMBL6253604 | 0.81 | MEN1 (0.67) | MEN1KMT2AKDM4EADORA2AADORA1 | |
| SCHEMBL3065335 | 0.80 | KDM4E (0.68) | MEN1KMT2AKDM4EADORA2AADORA1 | |
| SCHEMBL6250924 | 0.78 | PDE3A (0.71) | MEN1KMT2AKDM4EADORA2AADORA1 | |
| SCHEMBL6253687 | 0.78 | MEN1 (0.69) | MEN1KMT2AKDM4EADORA2AADORA1 | |
| SCHEMBL7549675 | 0.78 | MEN1 (0.61) | MEN1KMT2AKDM4EADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1222170-A1 | NOVEL NICOTINONITRILE COMPOUNDS | AstraZeneca AB (SE) | 2002-07-17 | — | — | EP | claimed |
| WO-2001025207-A1 | NOVEL NICOTINONITRILE COMPOUNDS | ASTRAZENECA AB (SE) | 2001-04-12 | — | — | WO | claimed |