Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.76 |
| ▸ | MEN1 | O00255 | 3/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.76 |
| ▸ | GLA | P06280 | 3/20 | 0.76 |
| ▸ | MAPT | P10636 | 2/20 | 0.76 |
| ▸ | GAA | P10253 | 1/20 | 0.76 |
| ▸ | GFER | P55789 | 1/20 | 0.76 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.76 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.74 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.63 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.61 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6250197 | 0.90 | MEN1 (0.87) | KDM4EALDH1A1MEN1KMT2AGLA | |
| SCHEMBL7501358 | 0.89 | MEN1 (0.70) | KDM4EALDH1A1MEN1KMT2AGLA | |
| SCHEMBL7509621 | 0.87 | KDM4E (0.71) | KDM4EALDH1A1MEN1KMT2AGLA | |
| SCHEMBL7510328 | 0.87 | KDM4E (0.71) | KDM4EALDH1A1MEN1KMT2AGLA | |
| SCHEMBL7501557 | 0.85 | MEN1 (0.72) | KDM4EALDH1A1MEN1KMT2AGLA | |
| SCHEMBL7505116 | 0.85 | KDM4E (0.84) | KDM4EALDH1A1MEN1KMT2AGLA | |
| SCHEMBL31120373 | 0.85 | KMT2A (0.79) | KDM4EALDH1A1MEN1KMT2AGLA | |
| SCHEMBL6252557 | 0.85 | KMT2A (0.79) | KDM4EALDH1A1MEN1KMT2AGLA | |
| SCHEMBL23841107 | 0.84 | KDM4E (0.82) | KDM4EALDH1A1MEN1KMT2AGLA | |
| SCHEMBL5470565 | 0.84 | KDM4E (0.66) | KDM4EALDH1A1MEN1KMT2AGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1222170-A1 | NOVEL NICOTINONITRILE COMPOUNDS | AstraZeneca AB (SE) | 2002-07-17 | — | — | EP | disclosed |
| WO-2001025207-A1 | NOVEL NICOTINONITRILE COMPOUNDS | ASTRAZENECA AB (SE) | 2001-04-12 | — | — | WO | disclosed |