Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 9/20 | 0.77 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14198337 | 0.90 | HRH1 (0.80) | HRH1KCNH2KDM4ECHRM1PDE10A | |
| SCHEMBL19770379 | 0.89 | HRH1 (0.95) | HRH1KCNH2 | |
| SCHEMBL17898450 | 0.87 | HRH1 (1.00) | HRH1KCNH2CHRM1 | |
| SCHEMBL17895346 | 0.87 | HRH1 (0.87) | HRH1KCNH2 | |
| SCHEMBL19770377 | 0.86 | HRH1 (0.85) | HRH1KCNH2 | |
| SCHEMBL991263 | 0.86 | HRH1 (0.73) | HRH1KCNH2KDM4ECHRM1PDE10A | |
| SCHEMBL19770376 | 0.85 | HRH1 (0.91) | HRH1KCNH2 | |
| SCHEMBL17888843 | 0.85 | HRH1 (1.00) | HRH1KCNH2 | |
| SCHEMBL17888850 | 0.85 | HRH1 (1.00) | HRH1KCNH2 | |
| SCHEMBL30306737 | 0.85 | HRH1 (0.83) | HRH1KCNH2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888336-B1 | NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL-AMINO)P IPERIDIN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | AVENTIS PHARMA INC (US) | 2002-08-07 | — | — | EP | disclosed |
| US-5922737-A | Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases | HOECHST MARION ROUSSEL, INC. (US) | 1999-07-13 | — | — | US | disclosed |
| EP-0888336-A1 | NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL-AMINO)P IPERIDIN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | HOECHST MARION ROUSSEL, INC. (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997030989-A1 | NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL-AMINO)PIPERIDIN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | HOECHST MARION ROUSSEL, INC. (US) | 1997-08-28 | — | — | WO | disclosed |