Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 15/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.47 |
| ▸ | GNG2 | P59768 | 1/20 | 0.34 |
| ▸ | GNB1 | P62873 | 1/20 | 0.34 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12094828 | 0.82 | MAPT (0.42) | SLC18A3 | |
| SCHEMBL4502421 | 0.80 | ALDH1A1 (0.47) | GSK3BSLC18A3 | |
| SCHEMBL4342076 | 0.78 | KMT2A (0.39) | PTPN1SLC18A3 | |
| SCHEMBL11726606 | 0.76 | AKR1B1 (0.42) | SLC18A3 | |
| SCHEMBL7325386 | 0.76 | KMT2A (0.43) | — | |
| SCHEMBL29941295 | 0.74 | L3MBTL1 (0.50) | — | |
| SCHEMBL334557 | 0.74 | — | — | |
| SCHEMBL24702053 | 0.73 | GSK3B (0.50) | GSK3BPTPN1 | |
| SCHEMBL5269154 | 0.73 | ALDH1A1 (0.37) | PTPN1SLC18A3 | |
| Hydrochloric Acid SCHEMBL11715676 | 0.72 | TSHR (0.42) | SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001934-B1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2002-11-27 | — | — | EP | disclosed |
| US-6300363-B1 | USEFUL IN THE TREATMENT OR ALLEVIATION OF INFLAMMATION AND OTHER INFLAMMATION ASSOCIATED DISORDERS IN MAMMALS | PFIZER INC. | 2001-10-09 | — | — | US | disclosed |
| EP-1001934-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999005104-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-02-04 | — | — | WO | disclosed |