Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | NAMPT | P43490 | 2/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.55 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 1/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6290759 | 0.87 | MEN1 (0.74) | MEN1KMT2ALMNASMN1; SMN2CYP19A1 | |
| SCHEMBL18725052 | 0.86 | KEAP1 (0.71) | CA1CA2CA9LMNASMN1; SMN2 | |
| SCHEMBL15651151 | 0.85 | CA12 (0.59) | CA1CA2CA9LMNASMN1; SMN2 | |
| SCHEMBL533757 | 0.85 | LMNA (0.56) | LMNASMN1; SMN2NAMPTCYP19A1CYP2C19 | |
| SCHEMBL9954386 | 0.84 | CYP19A1 (0.58) | MEN1KMT2ASMN1; SMN2NAMPTCYP19A1 | |
| SCHEMBL534569 | 0.84 | LMNA (0.63) | CA1CA2CA9LMNASMN1; SMN2 | |
| SCHEMBL4663044 | 0.82 | KEAP1 (0.76) | MEN1KMT2ACA1CA2CA9 | |
| SCHEMBL6276329 | 0.81 | NAMPT (0.68) | LMNASMN1; SMN2NAMPTCYP2C19MAPT | |
| SCHEMBL28413113 | 0.81 | NAMPT (0.64) | LMNASMN1; SMN2NAMPTCYP19A1KEAP1 | |
| SCHEMBL12980865 | 0.81 | TP53 (0.50) | LMNASMN1; SMN2NAMPTCYP2C19IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430011-A1 | 5-PYRIDIN-3-YL-1,3-DIHYDRO-INDOL-2-ON DERIVATIVES AND THEIR USE AS MODULATORS OF ALDOSTERONE SYNTHASE AND/OR CYP11B1 | Novartis AG (CH) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010130794-A1 | 5-PYRIDIN-3-YL-1,3-DIHYDRO-INDOL-2-ON DERIVATIVES AND THEIR USE AS MODULATORS OF ALDOSTERONE SYNTHASE AND/OR CYP11B1 | NOVARTIS AG (CH) | 2010-11-18 | — | — | WO | disclosed |