Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.67 |
| ▸ | RAB9A | P51151 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.67 |
| ▸ | RELA | Q04206 | 1/20 | 0.67 |
| ▸ | PLK1 | P53350 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MMP1 | P03956 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19723265 | 0.90 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL13611509 | 0.88 | NPC1 (0.77) | NPC1RAB9ASMN1; SMN2NFKB1MAPT | |
| Hydrochloric Acid SCHEMBL4251134 | 0.86 | NPC1 (0.74) | NPC1RAB9ASMN1; SMN2NFKB1MAPT | |
| SCHEMBL24385912 | 0.85 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2NFKB1MAPT | |
| SCHEMBL3209637 | 0.84 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2NFKB1MAPT | |
| SCHEMBL5032803 | 0.83 | PLK1 (0.71) | NPC1RAB9ASMN1; SMN2NFKB1MAPT | |
| SCHEMBL19486142 | 0.82 | PLK1 (0.49) | NPC1RAB9ASMN1; SMN2NFKB1MAPT | |
| SCHEMBL11758728 | 0.81 | NPC1 (0.77) | NPC1RAB9ASMN1; SMN2NFKB1MAPT | |
| SCHEMBL7207554 | 0.81 | NPC1 (0.73) | NPC1RAB9ASMN1; SMN2NFKB1MAPT | |
| SCHEMBL23254612 | 0.80 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2NFKB1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138209-B2 | Substituted picolinamides as MAO-B inhibitors useful for treating obesity | JENRIN DISCOVERY, INC. (US) | 2012-03-20 | — | — | US | disclosed |
| US-20070015734-A1 | MAO-B INHIBITORS USEFUL FOR TREATING OBESITY | JENRIN DISCOVERY (US) | 2007-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015734-A1 | MAO-B INHIBITORS USEFUL FOR TREATING OBESITY | MAOB, MAOA, GPR119 | NPC1 1101/4885RAB9A 2997/4885SMN1; SMN2 3865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.