Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 16/20 | 0.52 |
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.52 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7509353 | 0.84 | TLR8 (0.54) | TLR8TLR7PRKCZALDH1A1MAPT | |
| SCHEMBL10325225 | 0.83 | TLR8 (0.53) | TLR8TLR7ALDH1A1MAPT | |
| SCHEMBL8188956 | 0.82 | TLR8 (0.53) | TLR8TLR7PRKCZALDH1A1LMNA | |
| SCHEMBL10326208 | 0.81 | TLR8 (0.55) | TLR8TLR7 | |
| SCHEMBL10325490 | 0.81 | TLR8 (0.59) | TLR8TLR7 | |
| SCHEMBL10325903 | 0.81 | TLR8 (0.58) | TLR8TLR7LMNA | |
| SCHEMBL10345313 | 0.81 | TLR8 (0.67) | TLR8TLR7ALDH1A1MAPTNPSR1 | |
| SCHEMBL7515216 | 0.81 | TLR8 (0.70) | TLR8TLR7ALDH1A1MAPK1NPSR1 | |
| SCHEMBL7505631 | 0.80 | TLR8 (0.63) | TLR8TLR7ALDH1A1LMNA | |
| SCHEMBL10345314 | 0.80 | TLR8 (0.57) | TLR8TLR7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825186-B1 | 2-Aminobenzazepine derivatives and their use for the treatment of immunosuppression | PFIZER (US) | 2002-04-17 | — | — | EP | disclosed |
| US-6043238-A | 2-Aminobenzazapine derivatives | PFIZER INC. (US) | 2000-03-28 | — | — | US | disclosed |