Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.53 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10326201 | 0.91 | TLR8 (0.56) | TLR8TLR7ALDH1A1HPGDKDM4E | |
| SCHEMBL8179545 | 0.91 | TLR8 (0.60) | TLR8TLR7CA12CA9ALDH1A1 | |
| SCHEMBL10326042 | 0.88 | TLR8 (0.61) | TLR8TLR7ALDH1A1HPGDKDM4E | |
| SCHEMBL8179510 | 0.88 | CA12 (0.55) | TLR8TLR7CA12CA9CA2 | |
| SCHEMBL7509353 | 0.85 | TLR8 (0.54) | TLR8TLR7ALDH1A1HPGDKDM4E | |
| SCHEMBL10325225 | 0.84 | TLR8 (0.53) | TLR8TLR7ALDH1A1KDM4ENPC1 | |
| SCHEMBL8188907 | 0.84 | CA12 (0.41) | TLR8CA12CA9CA2ALDH1A1 | |
| SCHEMBL8179986 | 0.83 | TLR8 (0.54) | TLR8TLR7ALDH1A1HPGDKDM4E | |
| SCHEMBL10343253 | 0.83 | TLR8 (0.62) | TLR8TLR7 | |
| SCHEMBL10325490 | 0.82 | TLR8 (0.59) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043238-A | 2-Aminobenzazapine derivatives | PFIZER INC. (US) | 2000-03-28 | — | — | US | disclosed |
| EP-0825186-A1 | 2-Aminobenzazepine derivatives and their use for the treatment of immunosuppression | PFIZER INC. (US) | 1998-02-25 | — | — | EP | disclosed |