Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 10/20 | 0.70 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.70 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12653194 | 0.85 | TLR8 (0.83) | TLR8TLR7 | |
| SCHEMBL7509353 | 0.83 | TLR8 (0.54) | TLR8TLR7KDM4ESMN1; SMN2TSHR | |
| SCHEMBL10325225 | 0.82 | TLR8 (0.53) | TLR8TLR7KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL12653050 | 0.82 | TLR8 (1.00) | TLR8TLR7 | |
| SCHEMBL8188956 | 0.81 | TLR8 (0.53) | TLR8TLR7KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL7503802 | 0.81 | TLR8 (0.52) | TLR8TLR7MAPK1NPSR1ALDH1A1 | |
| SCHEMBL10325490 | 0.81 | TLR8 (0.59) | TLR8TLR7 | |
| SCHEMBL10325903 | 0.80 | TLR8 (0.58) | TLR8TLR7 | |
| SCHEMBL10345313 | 0.80 | TLR8 (0.67) | TLR8TLR7KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL7505631 | 0.79 | TLR8 (0.63) | TLR8TLR7HSD17B10TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825186-B1 | 2-Aminobenzazepine derivatives and their use for the treatment of immunosuppression | PFIZER (US) | 2002-04-17 | — | — | EP | disclosed |
| US-6043238-A | 2-Aminobenzazapine derivatives | PFIZER INC. (US) | 2000-03-28 | — | — | US | disclosed |
| EP-0825186-A1 | 2-Aminobenzazepine derivatives and their use for the treatment of immunosuppression | PFIZER INC. (US) | 1998-02-25 | — | — | EP | disclosed |