Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QDPR | P09417 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MIF | P14174 | 12/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | GHSR | Q92847 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7505583 | 0.93 | RAB9A (0.45) | QDPRRAB9AMIFHDAC6NPC1 | |
| SCHEMBL7501044 | 0.91 | RAB9A (0.43) | QDPRRAB9AMIFHDAC6NPC1 | |
| SCHEMBL7501060 | 0.91 | RAB9A (0.43) | QDPRRAB9AMIFHDAC6NPC1 | |
| SCHEMBL7507907 | 0.91 | RAB9A (0.48) | RAB9AMIFHDAC6NPC1SMN1; SMN2 | |
| SCHEMBL7504576 | 0.88 | NAMPT (0.48) | RAB9AMIFHDAC6NPC1SMN1; SMN2 | |
| SCHEMBL7508392 | 0.84 | RAB9A (0.43) | RAB9AMIFHDAC6NPC1SMN1; SMN2 | |
| SCHEMBL7505771 | 0.82 | MIF (0.38) | RAB9AMIFHDAC6NPC1SMN1; SMN2 | |
| SCHEMBL7503942 | 0.80 | MIF (0.43) | MIFHDAC6 | |
| SCHEMBL7507914 | 0.80 | RAB9A (0.46) | RAB9AMIFHDAC6NPC1SMN1; SMN2 | |
| SCHEMBL7508461 | 0.80 | MIF (0.38) | RAB9AMIFHDAC6NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920421-B1 | ISOXAZOLINE DERIVATIVES USEFUL AS ANTIMICROBIALS | UPJOHN CO (US) | 2002-11-06 | — | — | EP | claimed |
| US-5990136-A | EFFECTIVE AGAINST GRAMPOSITIVE AEROBIC BACTERIA, E.G. MULTIPLY-RESISTANT STAPHYLOCOCCI AND STREPTOCOCCI, AS WELL AS ANAEROBIC ORGANISMS, E.G. BACTEROIDES, CLOSTRIDIA, MYCOBACTERIUM TUBERCULOSIS AND MYCOBACTERIUM AVIUM | PHARMACIA & UPJOHN COMPANY (US) | 1999-11-23 | — | — | US | claimed |
| EP-0920421-B1 | ISOXAZOLINE DERIVATIVES USEFUL AS ANTIMICROBIALS | UPJOHN CO (US) | 2002-11-06 | — | — | EP | disclosed |
| US-6093736-A | ANTIBACTERIAL AGENTS | PHARMACIA & UPJOHN COMPANY | 2000-07-25 | — | — | US | disclosed |
| US-5990136-A | EFFECTIVE AGAINST GRAMPOSITIVE AEROBIC BACTERIA, E.G. MULTIPLY-RESISTANT STAPHYLOCOCCI AND STREPTOCOCCI, AS WELL AS ANAEROBIC ORGANISMS, E.G. BACTEROIDES, CLOSTRIDIA, MYCOBACTERIUM TUBERCULOSIS AND MYCOBACTERIUM AVIUM | PHARMACIA & UPJOHN COMPANY (US) | 1999-11-23 | — | — | US | disclosed |
| EP-0920421-A1 | ISOXAZOLINE DERIVATIVES USEFUL AS ANTIMICROBIALS | PHARMACIA & UPJOHN COMPANY (US) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998007708-A1 | ISOXAZOLINE DERIVATIVES USEFUL AS ANTIMICROBIALS | PHARMACIA & UPJOHN COMPANY (US) | 1998-02-26 | — | — | WO | disclosed |